This study is looking for people with REM sleep behavior disorder (RBD), a condition where you act out your dreams, and healthy volunteers. People with RBD often develop conditions like Parkinson's disease or Lewy body dementia later on. This study isn't testing a new treatment yet. Instead, it's preparing for future studies by collecting information like clinical assessments, blood samples, and brain scans (neuroimaging) from 500 participants. This data will help researchers understand synucleinopathies (a group of brain disorders) in their early stages and build a list of people who might be interested in future treatment trials. The main goal is to track changes using a scale called the Prodromal Synucleinopathy Rating Scale for up to five years.

Study design

This is an observational study, meaning no specific intervention is being tested. It plans to enroll 500 participants.

What's involved

If you have RBD, you would have a clinical assessment, fill out questionnaires, give blood, have brain scans (MRI and DaTscan), undergo two overnight sleep studies, and potentially a spinal tap (lumbar puncture). Healthy volunteers would have similar procedures, but only one MRI and an optional lumbar puncture.

Compensation

Not stated in the trial record.

Follow-up

Participants will be followed for up to 5 years to measure changes on the Prodromal Synucleinopathy Rating Scale.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.