NCT05826912
Multi-Arm Multi-Stage Adaptive Platform Trial (APT) for the Acute Treatment of Traumatic Brain Injury
Enrolling by Invitation
PHASE2Ages 18–65InterventionalTreatmentUniversity of California, San FranciscoInvestigator-initiated
~672 participants
Updated 2025-12-22 on ClinicalTrials.gov
What's tested:Atorvastatin CalciumMinocycline HydrochlorideCandesartan CilexetilPlacebo
At a glance
Recruiting sites
0 of 18 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Glasgow Outcome Scale-Extended (GOSE 2-Way)
Measured over 2 weeks to 3 months postinjury
Conditions
Where it's being run
18 sites across 13 statesTexas3
North Carolina2
Pennsylvania2
Wisconsin2
California1
Indiana1
Kentucky1
Massachusetts1
Study leadership
- Geoffrey Manley, MD PhD · PRINCIPAL_INVESTIGATOR · University of California, San Francisco
Who to contact
This trial hasn't published a contact. View it on ClinicalTrials.gov
What this trial measures
- Change in Glasgow Outcome Scale-Extended (GOSE 2-Way)2 weeks to 3 months postinjury
Functional impairment due only to the TBI will be measured using the GOSE Scale-Extended (GOSE 2-Ways). The score ranges from 1-8, with higher scores indicating better recovery. Change will be measured from Week 2 to Month 3 postinjury and compared to placebo.