Up-2 Study: Cognitively Engaging Walking Exercise and Neuromodulation to Enhance Brain Function in Older Adults

{ "Up-2 Study: Cognitively Engaging Walking Exercise and Neuromodulation for Older Adults", "This study is looking at whether combining special walking exercises with a type of brain stimulation can help older adults who are experiencing some memory or thinking problems and difficulty with movement. The study will test if a non-invasive electrical brain stimulation called Prefrontal Active tDCS (transcranial direct current stimulation) is more helpful than a \"sham\" (inactive) version of the stimulation. All participants will do walking exercises that involve complex tasks like stepping over obstacles. Researchers will measure changes in walking speed during obstacle tasks and scores on tests of executive function (a type of thinking skill) to see if the interventions are effective. You might be able to join if you are 65 or older and have experienced some decline in your thinking abilities.", "design": "This interventional study plans to enroll up to 120 older adults. It will compare Prefrontal Active tDCS with Prefrontal Sham tDCS, both combined with walking exercise.", "commitments": "You would participate in 18 sessions over a 6-week period, with each session including 30 minutes of walking and 20 minutes of tDCS. Assessments will be done at the beginning, after the 6-week intervention, and 12 weeks later.", "compensation": "Not stated in the trial record.", "follow_up": "Participants will be followed for about 12 weeks after the intervention period ends.", }

Study design
Not specified.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05830942

Up-2 Study: Cognitively Engaging Walking Exercise and Neuromodulation to Enhance Brain Function in Older Adults

Recruiting
NAAges 65+InterventionalTreatment
University of Florida
~120 participants
Updated 2026-06-03 on ClinicalTrials.gov
What's tested:Walking ExercisePrefrontal Active tDCSPrefrontal Sham tDCS

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
walking speed for obstacle task negotiation task
Measured over baseline, post-intervention (an average of 6 weeks after baseline), follow-up (an average of 12 weeks after post-intervention)
+1 more outcome measured
Cognitive Dysfunction
Mobility Limitation
Frail Elderly

NCT05830942

Where you'd take part

This study runs at 2 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Brooks Rehabilitation

    Jacksonville, Floridastudy coordinator listed

    Recruiting

  • University of Florida

    Gainesville, Floridastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • David J Clark, ScD · PRINCIPAL_INVESTIGATOR · University of Florida

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Eligibility criteria

Inclusion

Age 65+
Objective executive function decline, based on standardized cognitive assessments.
Subjective cognitive decline, based on the question: "During the past 12 months, have you experienced confusion or memory loss that is happening more often or getting worse?"
Ability to walking independently for 6 minutes (use of cane permitted)

Exclusion

Major cognitive disorder that interferes with independence
Percentile score less than 10th percentile on standardized cognitive assessments
Medications that are thought to influence tDCS neuroplasticity.
Contraindications to tDCS or MRI.
  • walking speed for obstacle task negotiation taskbaseline, post-intervention (an average of 6 weeks after baseline), follow-up (an average of 12 weeks after post-intervention)

    change in walking speed from baseline to post intervention (or follow-up) timepoint

  • score on test of executive functionbaseline, post-intervention (an average of 6 weeks after baseline), follow-up (an average of 12 weeks after post-intervention)

    change in score from baseline to post intervention (or follow-up) timepoint