The INFLUENTIAL Trial: Improving Inpatient Influenza Vaccination

This study, called The INFLUENTIAL Trial, is looking at ways to increase flu (influenza) vaccination rates for children who are in the hospital. Researchers are comparing current flu vaccination practices to a new, standardized inpatient flu vaccination program. This program might also include a learning collaborative, which is a group working together to improve practices. The study aims to see if these new programs can lead to more children getting their flu shot while hospitalized. You could be eligible to participate if you are at least 6 months old and admitted to a participating hospital unit, but not if you are in critical care or hematology-oncology services. The main goal is to measure the vaccine administration rate over one year. The current status of this study is unclear.

Study design
This interventional study plans to enroll 22,000 participants. It compares existing flu vaccination practices to a standardized inpatient flu vaccination program, with some sites also including a learning collaborative.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, vaccine administration rate, will be measured at 1 year.

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NCT05832307

The INFLUENTIAL Trial- Evaluation of National Inpatient Influenza Vaccination Program

Recruiting
NAAges 6–99InterventionalHealth services
University of Colorado, Denver
~22,000 participants
Updated 2026-04-08 on ClinicalTrials.gov
What's tested:Existing Influenza Vaccination PracticesStandardized inpatient influenza vaccination program

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Vaccine administration rate
Measured over 1 year
Influenza
2 sites across 2 states
Illinois1
Washington1
  • Suchitra Rao · PRINCIPAL_INVESTIGATOR · University of Colorado, Children's Hospital Colorado

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

At least 6 months of age
Admitted to an inpatient unit at a participating health system

Exclusion

At least 6 months of age
Admitted to an inpatient unit at a participating health system
  • Vaccine administration rate1 year

    proportion of influenza vaccine administrations to eligible patients during hospitalization.