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NCT05834829

Low-intensity Focused Ultrasound and Autonomic Response

Enrolling by Invitation
NAAges 18–65InterventionalBasic science
Virginia Polytechnic Institute and State University
~80 participants
Updated 2026-06-08 on ClinicalTrials.gov
What's tested:Low-intensity focused ultrasound neuromodulationSham Low-intensity focused ultrasound

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Sympathetic tone response - Heart Rate Variability (HRV)
Measured over through study completion, an average of 1 month
+4 more outcomes measured

Conditions

Autonomic Dysfunction

Explore related trials

Disorder of autonomic nervous system

Where it's being run

1 sites across 1 states
Virginia1

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Exclusion

Claustrophobia (scanning environment may be uncomfortable).
Contraindications to MRI: including pacemaker, aneurysm clips, neurostimulators, cochlear implants, metal in eyes, steel worker, or other implants.
Contraindications to CT: pregnancy
Active medical disorder or treatment with potential central nervous system (CNS) effects (e.g. Alzheimer's) -
History of neurologic disorder. (e.g. Parkinson's, Epilepsy, or Essential Tremor)
History of head injury resulting in loss of consciousness for \>10 minutes.
History of alcohol or drug dependence (through self-report).
History of cardiac disease
A current or prior use of any cardiac medication (e.g. beta blockers or other anti-arrhythmics)
A history of diabetes mellitus or use of diabetic medications (e.g. metformin).

What this trial measures

  • Sympathetic tone response - Heart Rate Variability (HRV)through study completion, an average of 1 month

    Changes in HRV

  • Sympathetic tone response - Heart Rate (HR)through study completion, an average of 1 month

    Changes in HR

  • Sympathetic tone response - Blood Pressure (BP)through study completion, an average of 1 month

    Changes in BP (systolic and diastolic pressure)

  • Sympathetic tone response - Electrodermal Response (EDR)through study completion, an average of 1 month

    Changes in EDR

  • Sympathetic tone response - Electroencephalography (EEG)through study completion, an average of 1 month

    Changes in low and high frequency power