This study is looking at how well MDMA-assisted Cognitive Processing Therapy (MDMA-aCPT) works for U.S. Military Veterans with severe Posttraumatic Stress Disorder (PTSD). You would either receive MDMA-aCPT, which combines MDMA (a drug) with therapy sessions, or Cognitive Processing Therapy (CPT), a standard therapy for PTSD. The study wants to see if MDMA-aCPT helps reduce PTSD symptoms more effectively than CPT. Researchers will measure changes in your PTSD symptoms using a special scale (CAPS-5) over about four months. They also want to understand if MDMA-aCPT can be used within the VA system. This study is currently recruiting 30 participants and is open to Veterans receiving care at specific VA healthcare systems.

Study design

This is an interventional study comparing two different treatments for PTSD. It plans to enroll 30 participants.

What's involved

You would attend non-drug preparatory and integration sessions, and three experimental sessions where MDMA HCl is given with therapy. You would also receive 8-15 sessions of Cognitive Processing Therapy.

Compensation

Not stated in the trial record.

Follow-up

Your PTSD symptoms will be measured from the start of the study to approximately 4 months after the baseline.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.