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Gaming for Chemotherapy-induced Nausea and Vomiting

This study is testing if a special game called eSSET-CINV, played on an iPad, can help older adults (age 60 and up) manage nausea and vomiting caused by chemotherapy. You could join if you're newly diagnosed with cancer, receiving certain types of chemotherapy, and speak English. Researchers want to see if playing this game reduces how severe your nausea and vomiting are and how often you need to use healthcare resources. The study is currently unclear on its recruitment status and plans to enroll 610 participants.

Study design
This is an interventional study where participants will be randomly assigned to either play the game at their first chemotherapy visit or later in the study. It aims to enroll 610 participants.
What's involved
Participants will play the serious game on an iPad at their first chemotherapy treatment visit if in the intervention group. You will be in the study for 6 chemotherapy treatment cycles, which could be 12 to 24 weeks.
Compensation
Not stated in the trial record.
Follow-up
Your healthcare resource use and CINV (chemotherapy-induced nausea and vomiting) severity will be measured from the start of the study through 12 or 24 weeks.

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NCT05838638

Serious Gaming for Chemotherapy-induced Nausea and Vomiting

Recruiting
NAAges 60+InterventionalSupportive care
University of Central Florida
~610 participants
Updated 2026-05-01 on ClinicalTrials.gov
What's tested:eSSET-CINV

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Healthcare resource use
Measured over From baseline through the end of the study at 12 or 24 weeks
+1 more outcome measured

Conditions

Neoplasms
Chemotherapy-induced Nausea and Vomiting

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Malignant Neoplasm

Where it's being run

2 sites across 1 states
Florida2

Study leadership

  • Victoria Loerzel, PhD · PRINCIPAL_INVESTIGATOR · University of Central Florida

Who to contact

Victoria Loerzel, PhD
[email protected]
407-823-0762
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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

age 60 or older
newly diagnosed with cancer
treatment with any chemotherapeutic agent of moderate or high emetic potential
on a 2, 3 or 4 week treatment cycle
proficient in English
has a telephone

Exclusion

previous diagnosis and/or treatment for cancer
end stage disease with less than 6 months to live
visually or hearing impaired without corrective device

What this trial measures

  • Healthcare resource useFrom baseline through the end of the study at 12 or 24 weeks

    any emergency department or hospital admission will be recorded using a dichotomous variable (yes/no)

  • CINV severityFrom baseline1 through the end of the study at 12 or 24 weeks

    The Symptom Management Checklist will measure the presence and severity of nausea and vomiting. Participants will be sent a text link every day for 6 days after chemotherapy or complete this data on a form at home. This starts right after time 1. Nausea will be reported on a 0-10 scale. Higher numbers equal more nausea.