Treatment of Orthostatic Hypotension in Spinal Cord Injury

This study is looking at ways to treat orthostatic hypotension (a sudden drop in blood pressure when standing up) in people with spinal cord injury. Researchers are testing a drug called Midodrine Hydrochloride to find the best dose to increase and stabilize your blood pressure when you change positions. They also want to understand how different treatments affect symptoms like fatigue and discomfort. You may be able to join if you are 18 to 60 years old, have a traumatic spinal cord injury (C1-T6 level) that happened at least 12 months ago, and are not able to walk or use a ventilator. The study aims to enroll 25 participants, but its current recruitment status is unclear. Success will be measured by changes in your systolic blood pressure (the top number in a blood pressure reading) over 3 years.

Study design
This is an interventional study planning to enroll 25 participants. The phase of the study is not specified.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your systolic blood pressure will be measured at 3 years to see the long-term effects of the treatment.

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NCT05839652

Treatment of Orthostatic Hypotension in SCI

Recruiting
PHASE4Ages 18–60InterventionalTreatment
James J. Peters Veterans Affairs Medical Center
~25 participants
Updated 2026-08-10 on ClinicalTrials.gov
What's tested:Midodrine Hydrochloride

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Systolic blood pressure
Measured over 3 years
Hypotension
2 sites across 2 states
New Jersey1
New York1

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

traumatic spinal cord injury
at least 12 months post injury
injury level of C1-T6
AIS A, B or C
non-ambulatory
non-ventilator

Exclusion

Active psychiatric disorder
Stroke or cerebrovascular disease
Alzheimer's Disease or dementia
Unmanaged cardiac arrhythmias
Concurrent systemic, hepatic, or renal disease
Suspected or diagnosed malignancy
Neurological disease other than SCI
Self-reported history of three or more symptomatic episodes of AD per day
  • Systolic blood pressure3 years

    determine differences in systolic blood pressure after midodrine, droxidopa, compression stockings and placebo