NSAID Use After Robotic Partial Nephrectomy

This study is looking at how well non-steroidal anti-inflammatory drugs (NSAIDs) like Ketorolac and Ibuprofen can manage pain after robotic-assisted partial nephrectomy (a surgery to remove part of the kidney due to kidney cancer). Researchers want to see if these medications can control pain effectively while reducing the need for opioid pain relievers like Oxycodone and Hydromorphone. You may receive Ketorolac, Acetaminophen, Oxycodone, Hydromorphone, or Ibuprofen. The main goal is to measure how much opioid medication is used in the 20 days after surgery. This study is for people aged 18 to 99 who are having this specific kidney surgery at the University of Miami Hospital and Network Sites.

Study design: This is an interventional study planning to enroll 110 participants. It is not specified if it is randomized or blinded.
What's involved: Not specified in the trial record.
Compensation: Not stated in the trial record.
Follow-up: The study measures opioid use for up to 20 days after surgery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NSAID Use After Robotic Partial Nephrectomy

Recruiting

PHASE2Ages 18–99InterventionalTreatment

University of Miami

~110 participants

Updated 2025-09-05 on ClinicalTrials.gov

What's tested:KetorolacAcetaminophenOxycodoneHydromorphoneIbuprofen

At a glance

Recruiting sites

1 of 1 listed site is recruiting right now

RecruitingSuspended, closed, or not yet open

What they're measuring

Rate of Opioid Use in Postoperative Period

Measured over Up to 20 days

Conditions

Kidney Cancer

Renal Cancer

Renal Neoplasm

NCT05842044

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

University of Miami
Miami, Floridastudy coordinator listed
Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

Mark L Gonzalgo, MD, PhD · PRINCIPAL_INVESTIGATOR · University of Miami

Who to contact

Mark L Gonzalgo, MD, PhD

[email protected]

305-243-3246

Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

Patients undergoing uncomplicated robotic assisted laparoscopic partial nephrectomy for renal mass at the University of Miami Hospital and Network Sites (Deerfield Beach, Plantation, Lennar (Coral Gables), and Kendal).

Age 18-99.

Ability to understand and the willingness to sign a written informed consent document.

Exclusion

Allergy to NSAIDs

Myocardial infarction or unstable angina within 12 months.

Any history of coronary artery bypass graft surgery.

History or active peptic ulcer disease, gastrointestinal (GI) bleeding, GI perforation. History of bleeding disorder. Glomerular filtration rate (GFR) \< 60 mL/min/1.73m2 (Modification of Diet in Renal Disease (MDRD) equation).

Taking any anti-platelet or anti-coagulation medications concurrently (e.g. warfarin, aspirin, clopidogrel, rivaroxaban etc.)

Chronic opioid use (use within 12 weeks) or history of opioid use disorder.

Solitary kidney.

Pregnancy.

Inability to give informed consent or unable to meet requirement of the study for any reason.

What this trial measures

Rate of Opioid Use in Postoperative PeriodUp to 20 days
Rate of opioid use is defined as the number of participants who used opioid medications during the post-operative period (defined as end of surgery to post-operative follow up visit) divided by total number of participants in the group at postoperative visit.

Trialytics