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Tailored Pain Guide (TPG) Study for Chronic Lower Back Pain

This study is looking at how an electronic, self-management website called PainGuide can help people with chronic lower back pain (pain lasting at least six months). You could be eligible if you are 18 or older, have chronic lower back pain, and a high score on a pain interference survey (PROMIS Pain Interference score of 60 or more). The study is testing two versions of PainGuide: a "Structured and tailored PainGuide" that provides weekly instructions and personalized messages, and a "Standard PainGuide" that doesn't send messages after you enroll. Researchers will measure your pain interference at the beginning and again at 24 weeks to see if the tailored version leads to greater improvement. The study plans to enroll 550 participants, but its current status is unclear.

Study design
This is an interventional study comparing two different versions of the PainGuide program. It aims to enroll 550 participants.
What's involved
You will complete one module a week for the first 4 weeks if in the tailored group. You will also complete surveys for 24 weeks, or 52 weeks if you are part of the Non-Pharma Sub-study.
Compensation
Not stated in the trial record.
Follow-up
Your pain interference will be measured at 24 weeks. Some participants will complete surveys for 52 weeks.

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NCT05843890

Tailored Pain Guide (TPG) Study

Recruiting
NAAges 18+InterventionalTreatment
University of Michigan
~550 participants
Updated 2026-03-09 on ClinicalTrials.gov
What's tested:Structured and tailored PainGuideStandard PainGuide

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Patient-Reported Outcomes Measurement Information System (PROMIS) Pain Interference score
Measured over Baseline, Week 24

Conditions

Chronic Lower Back Pain

Explore related trials

Lower Back Pain

Where it's being run

1 sites across 1 states
Michigan1

Study leadership

  • Daniel Clauw, MD · PRINCIPAL_INVESTIGATOR · University of Michigan

Who to contact

Beth Banner
[email protected]
734-998-5837
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Chronic Lower Back pain (cLBP) defined by the National Institutes of Health (NIH) Task Force Report on Research Standards for Chronic Low Back Pain, (i.e., low back pain present at least six months, and present more than half of those days.)
Individuals must have a score of greater or equal to (≥) 60 on PROMIS Pain Interference.
Non-Pharma Sub-study:

Exclusion

Current cancer related pain
Diagnosis of autoimmune disease
Unable to speak, write or read English
Visual or hearing difficulties
Pregnancy or breastfeeding
Any other diseases or conditions that would make a patient unsuitable for study participation as determined by the site principal investigators.

What this trial measures

  • Change in Patient-Reported Outcomes Measurement Information System (PROMIS) Pain Interference scoreBaseline, Week 24

    The PROMIS Pain Interference consists of 4-items that assess the degree to which pain interferes with various aspects of life. Items are scored on a 1 ("Not at all") to 5 ("Very much") scale with a range of 4 - 20. Higher scores indicate greater pain interference