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Pilot Study for Gastrointestinal Peritoneal Carcinomatosis Models

This pilot study is looking for people with gastrointestinal (GI) tumors, with or without peritoneal carcinomatosis (PC), who are having a planned surgery. The study aims to collect blood, fluid from the abdomen (ascites/peritoneal wash fluid), and tumor samples during your surgery. These samples will be used to create individual patient-derived vascularized micro-tumors (VMTs), which are tiny tumor models with blood vessel structures. Researchers will also use a special imaging technique called Optical Coherence Tomography Angiography (OCTA) to study the blood vessel patterns in peritoneal lesions. The goal is to better understand and develop new ways to study this type of cancer. This study is currently recruiting about 20 participants.

Study design
This is a pilot study, meaning it's a small-scale study to test feasibility. It plans to enroll about 20 participants.
What's involved
You would be asked to provide blood, ascites/peritoneal wash fluid, and tumor samples during your planned standard of care surgical procedure.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoints, which are the main things being measured, will be assessed for up to 4 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05844865

Patient Derived Vascularized MicroTumor Model of Gastrointestinal Peritoneal Carcinomatosis

Recruiting
NAAges 18+InterventionalBasic science
University of California, Irvine
~20 participants
Updated 2026-08-14 on ClinicalTrials.gov
What's tested:Biospecimen Collection (Blood, Ascites/Peritoneal Wash Fluid and/or Tumor Samples)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Establishment of angioarchitechture of peritoneal lesions through Optical Coherence Tomography Angiography (OCTA)
Measured over Up to 4 years
+1 more outcome measured

Conditions

Peritoneal Carcinomatosis
Gastrointestinal Peritoneal Carcinomatosis

Explore related trials

Malignant Digestive System NeoplasmPeritoneal Carcinomatosis

Where it's being run

1 sites across 1 states
California1

Study leadership

  • Maheswari Senthil, MD FACS · PRINCIPAL_INVESTIGATOR · Chao Family Comprehensive Cancer Center

Who to contact

Chao Family Comprehensive Cancer Center University of California, Irvine
[email protected]
1-877-827-7883
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Eligibility criteria

Inclusion

Patients must have a GI tumor
Must have planned standard of care surgical procedure
Age ≥ 18 years.
Ability to understand and the willingness to sign a written informed consent

What this trial measures

  • Establishment of angioarchitechture of peritoneal lesions through Optical Coherence Tomography Angiography (OCTA)Up to 4 years

    Establishment and evaluation of angioarchitecture of peritoneal lesions through OCTA imaging obtained during surgery.

  • Development of individual patient-derived peritoneal carcinomatosis (pdPC) vascularized micro-tumor (VMT)Up to 4 years

    Successful establishment of multicellular pdPC VMT models from metastatic and/or primary tumor tissue with increasing tumor volume over a 14 day period.