Surgeon-Initiated Bone Health Referral for Lower Extremity Arthroplasty

This study is looking at whether a special referral process from your surgeon for bone health can help patients who are having lower extremity arthroplasty (joint replacement surgery in the leg or foot). Researchers want to see if this "Surgeon-Initiated Bone Health Referral Pathway" can reduce problems like needing another surgery or having a fragility fracture (a broken bone from a minor fall) after your joint replacement. You might be able to join if you are over 50 and have osteoporosis (weak bones) confirmed by a DEXA scan. The study will compare this new referral pathway to the usual way doctors refer patients for bone health care. The goal is to see if this new approach leads to better outcomes for patients after surgery.

Study design
This study plans to enroll 2000 participants and will randomly assign them to either the bone health referral pathway or standard care. It is an interventional study, meaning participants will receive a specific intervention.
What's involved
Participants will be screened for osteoporosis using a DEXA scan. If assigned to the treatment arm, you would be referred to an endocrinologist for virtual consultation, receive additional bone health labs, and potentially start medication. If in the control arm, you would be told to follow up with your primary care provider.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for two years after their lower extremity arthroplasty to track the incidence of all-cause revision and fragility fractures.

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NCT05845021

Surgeon-Initiated Bone Health Referral Pathway in Patients Undergoing Lower Extremity Arthroplasty

Recruiting
NAAges 50+InterventionalPrevention
Johns Hopkins University
~2,000 participants
Updated 2025-10-14 on ClinicalTrials.gov
What's tested:Surgeon-Initiated Bone Health Referral Pathway

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Incidence of All-Cause Revision following Lower Extremity Arthroplasty
Measured over 2-years postoperatively
+1 more outcome measured
Osteoporosis
Arthroplasty Complications
Fragility Fracture
1 sites across 1 states
Maryland1
  • Savyasachi Thakkar, MD · PRINCIPAL_INVESTIGATOR · Johns Hopkins School of Medicine

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Eligibility criteria

Inclusion

\>50
DEXA-confirmed diagnosis of osteoporosis

Exclusion

Prior diagnosis of osteoporosis
Prior treatment for osteoporosis
  • Incidence of All-Cause Revision following Lower Extremity Arthroplasty2-years postoperatively

    2-year incidence of all-cause revision following lower extremity arthroplasty

  • Incidence of Fragility Fracture following Lower Extremity Arthroplasty2-years postoperatively

    2-year incidence of a fragility fracture in any location following lower extremity arthroplasty