Personalized Tobacco Treatment in Primary Care (MOTIVATE)

This study, called MOTIVATE, is looking at two different ways to help people stop smoking: "Precision Treatment" and "Usual Care." Precision Treatment uses your clinical, genetic, and biomarker information to give you personalized recommendations for quitting. Usual Care uses standard practice guidelines. Researchers want to see if Precision Treatment is more effective at helping people quit smoking and if it encourages doctors to prescribe more tobacco treatment medications. You might be able to join if you are 18 or older, smoke at least 5 cigarettes a day, and can speak English. The study will measure if you receive and use tobacco treatment medication, and if you stop smoking, all at 6 months after the intervention. The current status of this study is unclear.

Study design
This study is a randomized controlled trial involving 50 clinicians and 800 patients. Participants will be randomly assigned to either the Usual Care or Precision Treatment group.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your smoking cessation will be measured at 6 months after the intervention.

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NCT05846841

Personalized Tobacco Treatment in Primary Care (MOTIVATE)

Recruiting
NAAges 18+InterventionalTreatment
Washington University School of Medicine
~850 participants
Updated 2026-08-03 on ClinicalTrials.gov
What's tested:Precision TreatmentUsual Care

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Patient receipt of tobacco treatment medication for smoking cessation
Measured over 6 months post-intervention
+2 more outcomes measured
Physician's Role
Smoking Cessation
Smoking
1 sites across 1 states
Missouri1
  • Li-Shiun Chen, ScD, MD, MPH · PRINCIPAL_INVESTIGATOR · Washington University School of Medicine

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  • Patient receipt of tobacco treatment medication for smoking cessation6 months post-intervention

    This will be quantified by the proportion of enrolled patients who receive cessation medication.

  • Patient use of cessation medication6 months post-intervention

    This will be quantified by the proportion of patients taking any cessation medication from time of enrollment through 6 months post-intervention.

  • Patient smoking abstinence6 months post-intervention

    This will be quantified by the proportion of smokers with bioverified point-prevalent abstinence at 6 months.