This study, called RESTORE, is for people who have had a cardiac arrest (heart attack where the heart stops) and then develop refractory status epilepticus (ongoing seizures that don't stop with usual treatments). Researchers are comparing two ways to use intravenous anesthesia (medicine given through a vein) to stop these seizures. One method aims for 'burst suppression,' where the brain's electrical activity is mostly quieted. The other aims for 'seizure suppression,' stopping seizures without quieting the brain as much. The goal is to see which method is safer and more effective at controlling seizures within 48 hours. You might be able to join if you are 18 or older, had a non-traumatic cardiac arrest outside the hospital, are in a coma, and have these specific seizures.

Study design

This is a randomized study with 30 participants. Participants will be assigned by chance to receive either burst suppression or seizure suppression anesthesia, and the study team will know which treatment is given.

What's involved

Participants will receive intravenous anesthesia for 24 hours, which may be repeated for another 24 hours if seizures return. The anesthetic will then be slowly reduced while brain activity is monitored.

Compensation

Not stated in the trial record.

Follow-up

The main goal of the study is measured at 48 hours after treatment begins.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.