This study is testing a new way to help people with stress disorders, specifically post-traumatic stress. It combines a medication called propranolol with memory reactivation procedures. Propranolol is given an hour before each of six weekly sessions where you'll recall a traumatic memory. There are two groups: one where the memory recall is slightly changed (mismatch condition) and one where it's the same each time (standard condition). Researchers want to see if adding the 'mismatch' helps reduce your body's physical reactions (like heart rate) to traumatic memories more effectively. You may be able to join if you are 18-65 years old and have experienced a traumatic event that meets specific criteria for post-traumatic stress.

Study design

This interventional study plans to enroll 80 participants. Participants will be randomly assigned to one of two treatment groups: either the 'mismatch' memory reactivation with propranolol or the 'standard' memory reactivation with propranolol.

What's involved

You would have six weekly memory reactivation sessions, each lasting 10-20 minutes, with propranolol given 60 minutes beforehand. Your physical reactions will be measured at the start, after treatment, and at a follow-up.

Compensation

Not stated in the trial record.

Follow-up

Your physical reactions will be measured again at week 11, which is four weeks after the treatment ends.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.