Exercise Neuroprotection in Parkinson's Disease
This study is looking into how exercise affects inflammation in people with Parkinson's disease (PD) and older adults. Researchers believe that inflammation in the brain (neuroinflammation) plays a big role in the death of brain cells in PD. By understanding how exercise impacts this inflammation, they hope to find ways to slow down or stop the disease from getting worse (neuroprotection). The study involves 90 participants, including people with PD and healthy older adults, who will engage in two different levels of a 30-minute aerobic exercise. The main goal is to see how exercise changes inflammation levels in the body. To join, you need to be between 30 and 85 years old, have a neurologist-diagnosed PD (if applicable), and be able to do 30 minutes of moderate aerobic exercise.
- Study design
- This is an interventional study with 90 planned participants. It involves two intensity levels of aerobic exercise, with participants trying both conditions.
- What's involved
- You would participate in two separate 30-minute aerobic exercise sessions, one week apart. Blood samples will be taken before and after each session.
- Compensation
- Not stated in the trial record.
- Follow-up
- Measurements are taken 30 minutes before and 30 minutes after each exercise session, with the two conditions separated by one week. There is no mention of follow-up beyond this.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Exercise Neuroprotection in Parkinson's Disease
At a glance
Conditions
NCT05854524
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
Gait and Balance Laboratory, 217 Bigelow Health Sciences Building, UNLV
Las Vegas, Nevadastudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Merrill Landers, DPT, PhD · PRINCIPAL_INVESTIGATOR · University of Nevada, Las Vegas
Who to contact
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Inclusion
Exclusion
What this trial measures
- Exercise and inflammatory milieuBaseline measurement only
International Physical Activity Questionnaire (IPAQ) and blood serum levels of the following: interleukin-6 (IL-6), tumor necrosis factor alpha (TNF), interleukin-1β (IL-1β), interleukin-2 (IL-2), interleukin-10 (IL-10), c-reactive protein (CRP), RANTES, BDNF, VEGF, nerve growth factor (NGF), GDNF, Superoxide dismutase, catalase, glutathione peroxidase, total antioxidant capacity
- Inflammatory milieu comparison to controlsBaseline measurement only
Blood serum levels of the following: IL-6, TNF, IL-1β, IL-2, IL-10, CRP, RANTES, BDNF, VEGF, NGF, GDNF, Superoxide dismutase, catalase, glutathione peroxidase, total antioxidant capacity
- Exercise dose and biomarkers30 minutes prior to the exercise (pre measurement) and 30 minutes after completing the 30-minute aerobic exercise condition (post measurement) . Both conditions are separated by one week.
Change in blood serum levels of the following for the two different exercise conditions: IL-6, TNF, IL-1β, IL-2, IL-10, CRP, RANTES, BDNF, VEGF, NGF, GDNF, Superoxide dismutase, catalase, glutathione peroxidase, total antioxidant capacity, deglycase (DJ-1) protein, nonenzymatic antioxidants (Glutathione, Vitamin A, Vitamin C, Vitamin E).
- Biomarkers in Parkinson Disease30 minutes prior to the exercise (pre measurement) and 30 minutes after completing the 30-minute aerobic exercise condition (post measurement) . Both conditions are separated by one week
Change in blood serum levels of the following for people with Parkinson's disease and older adults: IL-6, TNF, IL-1β, IL-2, IL-10, CRP, RANTES, BDNF, VEGF, NGF, GDNF, Superoxide dismutase, catalase, glutathione peroxidase, total antioxidant capacity, DJ-1 protein, nonenzymatic antioxidants (Glutathione, Vitamin A, Vitamin C, Vitamin E).