Photobiomodulation for Cancer-Related Cognitive Impairment

This study is testing if a device called the THOR LED Photobiomodulation Helmet can help improve "chemo brain" or cancer-related cognitive impairment (problems with thinking, memory, and focus after cancer treatment). You might be able to join if you are an adult (18 or older) who has had certain types of cancer (stage I-III non-central nervous system solid tumor, Hodgkin, or Non-Hodgkin lymphoma) and finished your main cancer treatment (chemotherapy and/or radiation) between 6 months and 5 years ago. The study aims to see if using this helmet can positively impact cognitive symptoms. The current status of this study is unclear, and it plans to enroll 30 participants.

Study design
This is a pilot, randomized, double-blinded study with 30 participants. Participants will be assigned by chance to either receive the active treatment or a placebo (inactive) treatment.
What's involved
Participants will use the helmet device three times a week for six weeks. You will need to sit with the helmet on your head during each session, and protective goggles will be worn.
Compensation
Not stated in the trial record.
Follow-up
Your cognitive symptoms will be measured at a 1-month follow-up after the treatment period.

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NCT05855694

Photobiomodulation for Cancer-Related Cognitive Impairment

Not Yet Recruiting
NAAges 18+InterventionalSupportive care
Arash Asher, MD
~30 participants
Updated 2026-08-10 on ClinicalTrials.gov
What's tested:THOR LED Photobiomodulation Helmet - TherapeuticTHOR LED Photobiomodulation Helmet - Control

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Cognitive Symptoms
Measured over 1-Month Follow Up
Cancer-related Cognitive Impairment
1 sites across 1 states
California1
  • Arash Asher, MD · PRINCIPAL_INVESTIGATOR · Cedars-Sinai Medical Center

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Eligibility criteria

Inclusion

Adults ≥ 18 years
Previous diagnosis of stage I-III non-central nervous system solid tumor malignancy, Hodgkin, or Non-Hodgkin lymphoma
Completed cancer treatment (chemotherapy and/or radiation) more than 6 months ago but less than 5 years ago (Current concurrent endocrine therapy, anti-HER-2 therapy allowed, or other stable maintenance therapies (such as rituximab) will be allowed.
Self-reported cognitive complaints (score ≤ 54 on the Functional Assessment of Cancer Therapy-Cognition, Version 3, Perceived Cognitive Impairment subscale)
Written informed consent obtained from subject and ability for subject to comply with the requirements of the study.
Ability to read, write and understand either English OR Spanish.

Exclusion

Current pregnancy or nursing status
Current use of Photobiomodulation (PBM) (for any reason)
A lifetime history of any brain tumor or central nervous system metastasis
Previous use of intrathecal chemotherapy, chimeric antigen receptor treatment (CAR-T), or stem cell/marrow transplant
Known history of other neurological conditions involving impaired cognitive function (such as Alzheimer's Disease and related dementias, Parkinson's Disease, or Multiple Sclerosis).
  • Cognitive Symptoms1-Month Follow Up

    Cognitive symptoms will be measured by changes in scores on the PROMIS Cognitive Function-Short-Form 8a. Scores can range from 8-40. with higher score representing better outcomes.