Study on Opioid Effects on Diaphragm Muscle
This study is looking into how different doses of Fentanyl Injection (an opioid used for sedation) affect your diaphragm muscle's ability to generate force. Researchers want to understand if opioids impact how well this important breathing muscle works. You may be able to join if you are an adult undergoing lower extremity orthopedic surgery at St. Mary Hospital or Rochester Methodist Hospital within the Mayo Clinic Rochester system. The study aims to understand what changes occur in the diaphragm's stiffness (measured by Young's modulus) after receiving Fentanyl. The current recruitment status is unclear, and the study plans to enroll 69 participants.
- Study design
- This interventional study plans to enroll 69 adult participants. It will evaluate three different doses of Fentanyl Injection.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your diaphragm's stiffness will be measured at the start of the study and again 10 minutes after receiving the opioid.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
A Study to Investigate of the Effects of Opioid Exposure on the Ability of the Diaphragm Muscle
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Carlos Mantilla, MD, PhD · PRINCIPAL_INVESTIGATOR · Mayo Clinic
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
Do you actually qualify for this trial?
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Exclusion
What this trial measures
- Change in Young's modulus (derived from shear wave speed)Baseline, 10 min post-opioid
Measured by the ultrasound elastography of the diaphragm muscle reported in KPa