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Understanding Exercise Response in People with Obesity

This observational study aims to understand how long-term inflammation affects muscle function and how muscles respond to exercise in people with obesity. Researchers will use diagnostic tests like a Treadmill Test (to measure fitness), a Strength Test (for leg muscles), and Dual-Energy X-Ray Absorptiometry (to measure body composition). They will also take small samples of muscle (Muscle Biopsy) and fat (Fat Biopsy). The study is looking for 120 obese men and women between 20 and 45 years old. To join, you cannot have diabetes, anemia, or certain heart conditions. The main goal is to see how muscle protein synthesis changes after exercise, measured at the beginning and about 8 hours after exercise. The current recruitment status is unclear.

Study design
This is an observational study planning to enroll 120 participants. It is not specified if it is randomized or blinded.
What's involved
Participants will undergo a Treadmill Test, Strength Test, Dual-Energy X-Ray Absorptiometry, Muscle Biopsy, and Fat Biopsy. Muscle protein synthesis will be measured at baseline and approximately 8 hours post-exercise.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for approximately 8 hours post-exercise for the primary endpoint measurement.

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NCT05857150

Exercise Response in Humans With Obesity

Recruiting
Not specifiedAges 20–45Observational
Mayo Clinic
~120 participants
Updated 2025-08-29 on ClinicalTrials.gov
What's tested:Treadmill TestStrength TestDual-Energy X-Ray AbsorptiometryMuscle BiopsyFat BiopsyResting Energy Expenditure

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in muscle protein synthesis
Measured over Baseline, post-exercise approximately 8 hours

Conditions

Obese

Explore related trials

Obesity

Where it's being run

1 sites across 1 states
Minnesota1

Study leadership

  • Ian Lanza, PhD · PRINCIPAL_INVESTIGATOR · Mayo Clinic

Who to contact

Rachel Passehl
[email protected]
507-255-8112
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Obese men and women ≥ 20 and ≤ 45 years of age.

Exclusion

Diabetes or fasting plasma glucose \>126 mg/dL
Anemia (female subjects hemoglobin of \<11 g/dl and male subjects hemoglobin \<12 g/dl)
Active coronary artery disease or history of unstable macrovascular disease (unstable angina, myocardial infarction, stroke, and revascularization of coronary, peripheral or carotid artery within 3 months of recruitment)
Renal failure (serum creatinine \> 1.5mg/dl)
Chronic active liver disease defined as aspartate aminotransferase (AST)\>144 IU/L or alanine transaminase (ALT) \>165 IU/L)
Oral warfarin group medications or history of blood clotting disorders.
Smoking
Pregnancy or breastfeeding
Alcohol consumption greater than 2 glasses/day or other substance abuse
Untreated or uncontrolled hypothyroidism
Debilitating chronic disease (at the discretion of the investigators)

What this trial measures

  • Change in muscle protein synthesisBaseline, post-exercise approximately 8 hours

    Skeletal muscle protein synthesis will be measured from the rate of incorporation of infused amino acids measured by mass spectrometry.