Comparing TBT to Disorder-Specific Psychotherapy in Veterans With Social Anxiety Disorder

This study is looking at two types of talk therapy for Veterans with social anxiety disorder (SAD) and post-traumatic stress (PTSD). It compares Transdiagnostic Behavior Therapy (TBT), which is designed to help with several disorders at once, to Cognitive Behavioral Therapy for Social Anxiety Disorder (CBT for SAD), which focuses specifically on social anxiety. Researchers want to see if TBT can improve quality of life and reduce symptoms as effectively as CBT for SAD. The study will enroll about 264 Veterans who are registered at the Ralph H. Johnson Veterans Affairs Health Care System and have both social anxiety disorder and significant PTSD symptoms. Success will be measured by changes in how much your daily life is affected by your symptoms, your PTSD symptoms, and how much your illness interferes with your life, over 6 months.

Study design
This is an interventional study comparing two different behavioral therapies and plans to enroll 264 participants.
What's involved
You would participate in a study-specific intake appointment, including a clinical interview and questionnaires, and then receive one of the two therapies.
Compensation
Not stated in the trial record.
Follow-up
Your progress will be checked at 6 weeks, 12 weeks, and 6 months after starting the therapy.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05858346

Comparing TBT to Disorder-Specific Psychotherapy in Veterans With Social Anxiety Disorder

Recruiting
NAAges 18–80InterventionalTreatment
VA Office of Research and Development
~264 participants
Updated 2026-02-10 on ClinicalTrials.gov
What's tested:Transdiagnostic Behavior TherapyCognitive Behavioral Therapy for Social Anxiety Disorder

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
MASA functional impairment
Measured over change from baseline to week 6 to week 12 to 6-month followup
+2 more outcomes measured
Social Anxiety Disorder
1 sites across 1 states
South Carolina1
  • Daniel F Gros, PhD MA BS · PRINCIPAL_INVESTIGATOR · Ralph H. Johnson VA Medical Center, Charleston, SC

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Participants must be Veterans and registered at Ralph H. Johnson Veterans Affairs Health Care System
Participants must be clearly competent to provide informed consent for research participation
Participants must meet DSM-5 criteria for social anxiety disorder
Participants must have clinically significant symptoms of comorbid posttraumatic stress

Exclusion

recent history (\< 2 months) of psychiatric hospitalization or a suicide attempt as documented in their medical record,
acute, severe illness or medical condition that likely will interfere with study procedures as documented in their medical record
recent start of new psychiatric medication(s) (\< 4 weeks),
primary diagnosis of a condition associated with psychotic symptoms, personality disorder, substance use disorder, or bipolar disorder.
  • MASA functional impairmentchange from baseline to week 6 to week 12 to 6-month followup

    The MASA is a 38-item self-report measure that was designed to assess trait symptom dimensions consistent with the hybrid model of social anxiety. The MASA contains six subscales that assess behavioral avoidance, physiological arousal and avoidance, thought avoidance, anhedonia, functional impairment, and coping with substances. The six subscales have shown to differentiate symptoms across anxiety disorders and depression and their comorbidities and to be sensitive to improvements evidenced in therapy.

  • PTSD Checklist for DSM-5 (PCL-5)change from baseline to week 6 to week 12 to 6-month followup

    The PTSD Checklist for DSM-5 (PCL-5) is a 20-item self-report measure that assesses DSM-5 criteria PTSD symptoms. Items are scored on a 5-point scale, range from 0 (not at all) to 4 (extremely). The total scale score ranges from 0 to 80 with higher scores associated with more severe symptomatology. Previous versions of the PCL have been shown to have excellent internal consistency and excellent test-retest reliability in Veterans. In addition, the PCL-5 has been incorporated into standard assessment for PTSD at the VA. The PCL5 will be used to assess symptoms of PTSD.

  • Illness Intrusiveness Rating Scale (IIRS)change from baseline to week 6 to week 12 to 6-month followup

    The IIRS is a 13-item questionnaire that assesses the extent to which a disease interferes with important domains of life, including health, diet, work, and several others. The IIRS has been shown to have strong psychometric properties in the previous literature in participants with physical and emotional health concerns, and has been used in previous TBT studies.