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Breathing Training for Non-Cystic Fibrosis Bronchiectasis

This study is looking into whether a home-based breathing and muscle training program can help people with non-cystic fibrosis bronchiectasis (non-CFB) improve their ability to exercise, lung function, and overall health. You would use a device called LungTrainers, which provides resistance as you breathe out, along with a specific exercise routine. Researchers want to see if these interventions improve how far you can walk in six minutes and your peak oxygen uptake during exercise. To join, you need to be a Mayo Clinic patient with a confirmed diagnosis of non-CFB, between 21 and 80 years old. The study aims to enroll 50 participants, but its current recruitment status is unclear.

Study design
This is an interventional study planning to enroll 50 participants. It is testing a breathing device and a behavioral training program.
What's involved
You would use the LungTrainers device and follow a pulmonary rehabilitation regime 3-5 days per week for about 10 weeks. This involves one long session (20-30 minutes) or multiple shorter sessions daily.
Compensation
Not stated in the trial record.
Follow-up
Your progress will be measured at the start of the study and again after 8 weeks.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05860803

Breathing Training and Exercise Capacity in Non-CFB

Recruiting
NAAges 21–80InterventionalTreatment
Mayo Clinic
~50 participants
Updated 2026-01-06 on ClinicalTrials.gov
What's tested:LungTrainersLungTrainers Pulmonary Rehabilitation regime

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in six-minute walk test distance
Measured over Baseline, 8 weeks
+1 more outcome measured

Conditions

Non-cystic Fibrosis Bronchiectasis

Explore related trials

Non-cystic Fibrosis Bronchiectasis

Where it's being run

1 sites across 1 states
Florida1

Study leadership

  • Bryan Taylor, PhD · PRINCIPAL_INVESTIGATOR · Mayo Clinic

Who to contact

Federico Simon
[email protected]
904-953-4205
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Mayo Clinic patient with confirmed diagnosis of Non-Cystic Fibrosis Bronchiectasis (non-CFB): Non-CFB as confirmed by clinical history, including cough, shortness of breath, exertional dyspnea, pulmonary function tests, and high-resolution computed tomography. Patients will be considered clinically stable if there is no evidence of an exacerbation or change(s) in medical therapy in the previous three weeks.
Able and willing to provide informed consent to participate in the study.

Exclusion

Presence of significant coexisting disease, neurological conditions, and/or orthopedic complications that affect ability to undertake exercise.
Presence of advanced heart failure.
Current use of antibiotics.
Acute exacerbation(s) within 3-weeks prior to study commencement.
Participation within a pulmonary rehabilitation program within 6-months prior to study commencement.

What this trial measures

  • Change in six-minute walk test distanceBaseline, 8 weeks

    Measures the distance walked in meters for 6 minutes.

  • Change in peak oxygen uptake during maximal incremental exercise testBaseline, 8 weeks

    Maximum volume or amount of oxygen consumption during cardiopulmonary exercise test (treadmill or cycle).