Liposomal Bupivacaine and Transoral Robotic Surgery for Oropharyngeal Cancer

This observational study is for adults with oropharyngeal cancer (cancer of the middle part of the throat) who are having transoral robotic surgery (TORS). Researchers want to see if injecting EXPAREL® (Liposomal Bupivacaine), an FDA-approved pain medication, into the surgical area helps with pain and swallowing after surgery. They will compare patients who receive EXPAREL® to those who don't. The study will look at your pain control and swallowing ability (dysphagia) three months after surgery. You can join if you are 18 or older, having TORS, and can give consent. You cannot join if you are allergic to Bupivacaine or have a carnitine deficiency. The current status of this study is unclear.

Study design
This is an observational study involving 80 participants. It compares patients who receive Liposomal Bupivacaine to those who do not.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Your pain control and swallowing will be measured for 3 months after surgery.

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NCT05862792

Liposomal Bupivacaine and Transoral Robotic Surgery

Recruiting
Not specifiedAges 18+Observational
Geisinger Clinic
~80 participants
Updated 2025-09-09 on ClinicalTrials.gov
What's tested:Liposomal bupivacaine

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Postoperative Pain Control
Measured over 3 months
+2 more outcomes measured
Oropharyngeal Cancer
Dysphagia, Oropharyngeal
Post Operative Pain
Transoral Robotic Surgery
1 sites across 1 states
Pennsylvania1

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Eligibility criteria

Inclusion

Adult patients, greater than or equal to 18 years of age; Patients of all genders; Patients undergoing transoral robotic surgery; Patient who are able and willing to give consent

Exclusion

Patients with an allergy to Bupivacaine or other amide anesthetics; Patients with a carnitine deficiency
  • Postoperative Pain Control3 months

    We will be measuring subjects' postoperative maximum visual analog pain scores on each postoperative day. Scale: 0-10, 0 represents no pain and 10 represents the worst pain

  • Postoperative Dysphagia with Endoscopic Swallow Study3 months

    Patients will undergo a functional endoscopic swallow study with a speech language pathologist during their first postoperative visit.

  • Postoperative Dysphagia with Dysphagia Survey3 months

    Patients will undergo an evaluation of their swallow function via the MD Anderson Dysphagia Inventory survey with a speech language pathologist during their first postoperative visit.