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Observational Study on Neurosurgical Neuronavigation for Glioblastoma Multiforme

This study is looking at how a computer program, called a Support Vector Machine, can analyze brain scans taken before surgery for glioblastoma multiforme (a type of aggressive brain tumor). The goal is to see if this program can help predict how well a person's tumor will respond to treatment. You might be able to join if you are at least 18 years old, have a brain lesion that looks like glioblastoma multiforme on scans, and are planning to have a pre-operative MRI. The study will measure how many participants are considered short-term or long-term survivors over about two years. The current recruitment status is unclear.

Study design
This is an observational study with a planned enrollment of 100 participants.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed through completion of follow-up, estimated to be 2 years.

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NCT05864976

Neurosurgical Neuronavigation Using Resting State MRI and Machine Learning

Recruiting
Not specifiedAges 18+Observational
Washington University School of Medicine
~100 participants
Updated 2026-06-30 on ClinicalTrials.gov
What's tested:Support Vector Machine

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Number of participants who are deemed as short-term survivor or a long-term survivor
Measured over Through completion of follow-up (estimated to be 2 years)

Conditions

Glioblastoma Multiforme

Explore related trials

Glioblastoma

Where it's being run

1 sites across 1 states
Missouri1

Study leadership

  • Dimitrios Mathios, M.D. · PRINCIPAL_INVESTIGATOR · Washington University School of Medicine

Who to contact

Dimitrios Mathios, M.D.
[email protected]
314-747-6146
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Eligibility criteria

Inclusion

Must have a radiological diagnosis of a lesion in the brain with characteristics consistent with glioblastoma multiforme.
Must be planning to undergo a pre-operative MRI.
Must be at least 18 years old.
Must be able to understand and willing to sign an IRB approved written informed consent document.

Exclusion

Contraindication to MRI.
Inability to have clinical follow-up (e.g., patient is out of town and will do follow-up elsewhere).

What this trial measures

  • Number of participants who are deemed as short-term survivor or a long-term survivorThrough completion of follow-up (estimated to be 2 years)

    -Patients will be deemed as a short-term survivor or a long-term survivor and this will be defined as overall survival as less than or greater than 14.5 months, respectively.