Understanding Lung Changes in Post-COVID Conditions

This study is looking at how COVID-19 can affect your lungs long-term, specifically if you have ongoing symptoms like fatigue, shortness of breath (dyspnea), or difficulty exercising after having the virus. Researchers will use a special type of X-ray called a Computed Tomography (CT) scan of your chest to see how air moves in and out of your lungs and how blood flows through them. They want to understand if there are problems with ventilation (airflow) or perfusion (blood flow) in people with these long-term COVID symptoms. You might be able to join if you are 18 to 99 years old, had COVID-19 more than three months ago, and have new or worsening symptoms like chronic fatigue or shortness of breath, even if your standard lung tests are normal or only mildly abnormal. The study aims to see if these CT scans can help explain why some people have these ongoing issues.

Study design
This is an observational study involving about 40 participants. It's designed to describe patterns of lung ventilation and blood distribution.
What's involved
You would complete questionnaires, undergo pulmonary function tests, perform a 6-minute walk test, and have a low-dose CT scan of your chest.
Compensation
Not stated in the trial record.
Follow-up
Measures of regional lung ventilation and blood volume distribution will be taken at 1 day.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05866952

Ventilatory and Perfusion Abnormalities in Individuals With Post-Acute Sequelae of SARS-CoV-2 Infection

Recruiting
Not specifiedAges 18–99Observational
Tufts Medical Center
~40 participants
Updated 2025-07-20 on ClinicalTrials.gov
What's tested:Computed Tomography of the Chest

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Measures of regional lung ventilation
Measured over 1 day
+1 more outcome measured
Post-Acute COVID-19
Post COVID-19 Condition
Post Viral Fatigue
Dyspnea

NCT05866952

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Tufts Medical Center

    Boston, Massachusettsno site contact published

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

Age ≥ 18
Self-reported or documented SARS-CoV-2 infection by RT-PCR or Antigen testing \> 3 months ago or no previous history of SARS-CoV-2 infection (control group only)
Normal or mild abnormalities on baseline Pulmonary Function Tests (PFTs)
New or worsening symptoms of chronic fatigue, dyspnea or exercise intolerance after COVID-19 with otherwise unclear etiology (PASC group only)

Exclusion

SARS-CoV-2 infection by RT-PCR or Antigen testing within the last 3 months
Inability to provide consent or non-English speaking
Pregnancy
Any respiratory infection in last 4 weeks
PFT relative contraindications
History of major cardiovascular, pulmonary, renal, hepatic, autoimmune or neuromuscular disease including asthma, COPD, interstitial lung disease, heart failure, pulmonary arterial hypertension, or prior pulmonary embolism
Active malignancy undergoing treatment or history of malignancy involving the lung
  • Measures of regional lung ventilation1 day
  • Measures of blood volume distribution1 day