Belimumab for Systemic Sclerosis Associated Interstitial Lung Disease

This study is looking at a medication called belimumab to see if it can help adults with systemic sclerosis associated interstitial lung disease (SSc-ILD). SSc-ILD is a condition where the immune system attacks the lungs and other parts of the body. Researchers want to know if belimumab is safe and effective when added to standard treatments. They will compare belimumab to a placebo (an inactive substance) to see how it affects lung function, skin thickening, and general symptoms like fatigue and quality of life. The study plans to enroll 300 participants. The current status of the study is unclear.

Study design
This study is comparing belimumab to a placebo in 300 participants. It is an interventional study, meaning participants will receive a specific treatment.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint measures changes in lung function at Week 52, suggesting follow-up for at least 52 weeks.

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NCT05878717

A Study of the Efficacy and Safety of Belimumab in Adults With Systemic Sclerosis Associated Interstitial Lung Disease

Recruiting
PHASE2Ages 18+InterventionalTreatment
GlaxoSmithKline
~300 participants
Updated 2026-01-12 on ClinicalTrials.gov
What's tested:BelimumabPlacebo

At a glance

Recruiting sites
123 of 131 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Absolute change from baseline in Forced Vital Capacity (FVC) millilitre (mL) at Week 52
Measured over Baseline and Week 52
Systemic Sclerosis Associated Interstitial Lung Disease
Scleroderma, Systemic
131 sites across 32 states
China17
Italy15
Japan9
Spain9
Brazil8
France6
Israel6
Germany5
US GSK Clinical Trials Call Center
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  • Absolute change from baseline in Forced Vital Capacity (FVC) millilitre (mL) at Week 52Baseline and Week 52