Back to search results

AROMHA Brain Health Test for Cognitive Concerns

This study is looking at a new at-home smell test called the AROMHA Brain Health Test. Researchers want to see if this test can help identify people at risk for Alzheimer's disease or track how the disease progresses, even before clear memory problems appear. You can join if you are between 18 and 100 years old and have Subjective Cognitive Concerns (you feel your memory or thinking is changing), Mild Cognitive Impairment, Mild Behavioral Impairment, or are aging healthily. The goal is to see if the AROMHA test can be a simple, affordable way to tell the difference between normal aging and early signs of brain disorders.

Study design
This is an observational study aiming to enroll 250 participants. It is not specified if it's randomized or blinded.
What's involved
You will take the AROMHA Brain Health Test, which involves peeling and sniffing smell cards and answering questions on a web-based app. This test takes about 45 minutes.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint, the AROMHA Brain Health Test, is measured at 1 hour. Further follow-up is not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05881239

Digital Accessible Remote Olfactory Mediated Health Assessments for Preclinical AD

Recruiting
Not specifiedAges 18+Observational
Massachusetts General Hospital
~250 participants
Updated 2026-03-06 on ClinicalTrials.gov
What's tested:AROMHA Brain Health Test

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
AROMHA Brain Health Test
Measured over 1 hour

Conditions

Subjective Cognitive Concerns
Mild Cognitive Impairment
Mild Behavioral Impairment
Healthy Aging

Explore related trials

Alzheimer's DiseaseHealthy AgingMild Behavioral ImpairmentMild cognitive disorderSubjective Cognitive Concerns

Where it's being run

1 sites across 1 states
Massachusetts1

Study leadership

  • Mark W Albers, MD PhD · PRINCIPAL_INVESTIGATOR · Massachusetts General Hospital

Who to contact

Mark W Albers, MD PhD
[email protected]
617-724-7401
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

A clinical or research consensus diagnosis of the patient's condition or control status.
Individuals that are at least 18 years of age at the time of enrollment.
Individuals that are no older than 100 years of age at the time of enrollment.

Exclusion

Primary pulmonary disease such as severe emphysema or asthma not under good medical control.
Current sinusitis, common cold, upper respiratory infection, or nasal polyps.
Current or recent (past 6 months) alcohol or substance dependence. A prior history of alcohol or substance abuse will not be grounds for exclusion.
Pregnancy.
Severe cognitive dysfunction that would preclude completion of the olfactory testing.
An adverse reaction to fragrances (ie. they trigger a severe asthmatic attack or nausea).

What this trial measures

  • AROMHA Brain Health Test1 hour

    The AROMHA Brain Health Test is a battery of 18 odors across 5 smell cards. The subject smells each odor label and is tested on odor intensity, identification, memory, and discrimination. An increased number of correct responses indicates a better sense of smell. We will evaluate MCI patients' performance against age-matched controls.