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Electrical Stimulation for Nerve Injury Healing

This study is looking at whether a medical device called the Checkpoint BEST System can help nerves heal better after surgery for injuries in the arm. The device delivers a single, 10-minute dose of electrical stimulation during your surgery. You might be able to join if you are 18-80 years old, have an upper arm nerve injury that needs surgery (like a nerve transfer, repair, or graft), and are a candidate for surgical intervention. The study wants to see if this electrical stimulation improves how well your motor skills recover, which will be checked regularly for up to 18 months after surgery. This study plans to enroll 60 participants, but its current recruitment status is unclear.

Study design
This interventional study is randomized, meaning participants will be assigned by chance to either receive the electrical stimulation or not. It plans to enroll 60 participants.
What's involved
You would receive the Checkpoint BEST System during your surgery. Your motor recovery will be assessed at pre-surgery, and then at 2, 4, 6, 8, 10, 12, 15, and 18 months after surgery.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 18 months after surgery to assess motor recovery.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05884125

Promoting Healing of Injured Nerves With Electrical Stimulation Therapy

Completed
NAAges 18–80InterventionalTreatment
Checkpoint Surgical Inc.
~13 participants
Updated 2026-08-28 on ClinicalTrials.gov
What's tested:Checkpoint BEST System

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Motor Recovery assessed using the Medical Research Council (MRC) motor grading
Measured over Pre-surgery, 2 months, 4 months, 6 months, 8 months, 10 months, 12 months, 15 months, and 18 months

Conditions

Nerve Injury
Peripheral Nerve Injuries
Peripheral Nerve Injury Upper Limb
Nerve Palsy

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NCT05884125

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • The Ohio State Univeristy - Department of Plastic and Reconstructive Surgery

    Columbus, Ohiono site contact published

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Amy M Moore, MD · PRINCIPAL_INVESTIGATOR · Ohio State University

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

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Eligibility criteria

Inclusion

Upper extremity mixed or motor nerve injury from the brachial plexus to the wrist crease.
Candidate for surgical intervention.
Indicated for surgical repair by nerve transfer, primary repair, or nerve grafting.
Are age 18-80 years.
Signed and dated informed consent form.

Exclusion

Severe comorbid condition, such as arrhythmia or congestive heart failure, preventing surgery.
Primary repair requiring graft \>6cm.
Nerve reconstruction occurring \>12 months post injury.
Age less than 18 or greater than 80 years.
All contraindications to included/required surgical procedure, including but not limited to language barriers, mental status barriers, inability to consent, and pregnancy/lactation.

What this trial measures

  • Change in Motor Recovery assessed using the Medical Research Council (MRC) motor gradingPre-surgery, 2 months, 4 months, 6 months, 8 months, 10 months, 12 months, 15 months, and 18 months

    Grading of muscle strength on 0 to 5 scale, with higher score representing greater function.