This study is looking at how giving extra oxygen, called supplemental oxygen, helps adults who have a sudden blood clot in their lungs (acute pulmonary embolism or PE). Researchers want to see if breathing supplemental oxygen, delivered through a non-rebreather mask, can reduce the pressure in the lung arteries and improve how the right side of the heart works. You might be able to join if you are an adult (18 or older) with a recently confirmed PE, new or worsening symptoms, and your doctor has confirmed your heart's right side isn't working as well as it should, even if your oxygen levels are currently good. The main goal is to measure the pressure in your lung arteries at 30, 60, and 90 minutes after receiving either supplemental oxygen or regular room air. The study is currently unclear on its recruitment status.

Study design

This is an interventional study planning to enroll 80 adult participants. It is a randomized, crossover trial where participants will receive both supplemental oxygen and room air at different times.

What's involved

You would receive supplemental oxygen or room air for periods of 30, 60, and 90 minutes, and then for 180 minutes. After each treatment change and at 180 minutes, you would have echocardiograms and blood draws.

Compensation

Not stated in the trial record.

Follow-up

The primary measurements are taken at 30, 60, and 90 minutes after treatment, and then at 180 minutes.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.