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Understanding Heart Function in COPD Patients

This study is looking for people aged 40 and older with chronic obstructive pulmonary disease (COPD) to understand how their heart, specifically the right ventricle, works during rest and exercise. You would participate in an exercise session involving moderate and high-intensity activity. Researchers will use an echocardiogram (a type of ultrasound for the heart) to measure how well your right ventricle contracts during this time. The goal is to identify different patterns of right ventricular dysfunction to help find better treatments for COPD in the future. The study plans to enroll 60 participants, and its current recruitment status is unclear.

Study design
This is an interventional study planning to enroll 60 participants to observe their heart function during exercise.
What's involved
After a brief warm-up, you will perform about 5 minutes of moderate-intensity exercise and then about 2 minutes of high-intensity exercise. Your right ventricular contractility will be measured by echocardiography for up to 1 hour.
Compensation
Not stated in the trial record.
Follow-up
Right ventricular contractility is measured up to 1 hour after the intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05896579

Phenotyping Resting and Exertional Right Ventricular Dysfunction Among Patients With Chronic Obstructive Pulmonary Disease

Recruiting
NAAges 40+Interventional
University of Colorado, Denver
~60 participants
Updated 2026-05-08 on ClinicalTrials.gov
What's tested:Exercise

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Right ventricular contractility measured by transthoracic echocardiography
Measured over Up to 1 hour

Conditions

COPD
Pulmonary Hypertension
Right Ventricular Dysfunction
Exercise
Exercise Training

Explore related trials

Chronic Obstructive Pulmonary DiseaseExercisePulmonary HypertensionRight Ventricular Dysfunction

Where it's being run

1 sites across 1 states
Colorado1

Study leadership

  • Lindsay Forbes, MD · PRINCIPAL_INVESTIGATOR · University of Colorado, Denver

Who to contact

Lindsay Forbes, MD
[email protected]
(303)724-4020
Email the study team

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Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

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Eligibility criteria

Inclusion

COPD (determined by ratio of forced expiratory volume in 1 second to forced vital capacity \[FEV1/FVC\] \<0.7)
Age \>= 40 years

Exclusion

Exacerbation of COPD in the 3 months prior to enrollment
Change in COPD therapy in the 3 weeks prior to enrollment
Requirement of \>6 LPM supplemental oxygen at rest
Requirement of \>10 LPM supplemental oxygen with exertion
Active/uncontrolled cardiovascular disease (e.g. hypertension with blood pressure \>150/100 despite antihypertensives; coronary artery disease with angina; left ventricular ejection fraction ≤40%; arrhythmia; pulmonic, mitral or aortic valvular abnormality greater than mild in severity; tricuspid regurgitation greater than moderate in severity)
Volume overload (jugular vascular distension or greater than trace peripheral edema)
World Health Organization Functional Class IV
Known pulmonary hypertension with mean pulmonary artery pressure \>45 mmHg
Untreated severe obstructive sleep apnea or obesity hypoventilation syndrome
Active malignancy (other than skin)
Medical conditions that limit exercise on an upright stationary bicycle (e.g. severe osteoarthritis, imbalance/gait instability, etc.)
Pregnancy
Body mass index \<18 or \>40
Hematocrit \<25% or \>55%
For invasive CPET, chronic anticoagulation that is unable to be held for the study visit
For invasive CPET, forced expiratory volume in 1 second of \<20%

What this trial measures

  • Right ventricular contractility measured by transthoracic echocardiographyUp to 1 hour

    Global longitudinal strain, measured in absolute percent