This observational study aims to understand how certain genes related to type 1 diabetes (T1D) affect your immune system and lead to the development of T1D. Researchers are looking at genes like IFIH1, TYK2, and IKZF4, as well as your overall genetic risk. They want to see how these genes might cause immune cells to become self-reactive, meaning they mistakenly attack your own body, and how they affect the function of different immune cells (T cells and B cells). The study will involve a blood draw to collect samples. The main goals are to count how many participants become at risk for T1D and to assess their genetic risk for T1D, with measurements taken throughout the study, which could last up to 25 years. This study is currently unclear on its recruitment status and is open to people of all genders, aged 0 to 100 years, who are able to have blood drawn.

Study design

This is an observational study, meaning researchers will observe participants without providing any specific treatment. It plans to enroll 2800 participants.

What's involved

Participants will undergo a peripheral blood draw. The study duration for measuring primary outcomes can be up to 25 years.

Compensation

Not stated in the trial record.

Follow-up

Participants will be followed for up to 25 years to measure the number who become at risk for type 1 diabetes and their genetic risk.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.