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NCT05901233

Speech-Language Treatment With Remotely Supervised Transcranial Direct Current Stimulation in Primary Progressive Aphasia

Enrolling by Invitation
NAAll AgesInterventionalTreatment
University of Texas at Austin
~10 participants
Updated 2025-10-08 on ClinicalTrials.gov
What's tested:Remotely supervised Transcranial Direct Current Stimulation (RS-tDCS)Remotely supervised sham tDCS (RS-sham-tDCS)Lexical Retrieval Training (LRT)Video Implemented Script Training in Aphasia (VISTA)

At a glance

Recruiting sites
0 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
RS-LRT arm: Change in spoken naming
Measured over change from pre-treatment to one month and three months after onset of treatment in each phase (stimulation and sham)
+1 more outcome measured

Conditions

Primary Progressive Aphasia

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NCT05901233

Where you'd take part

This study runs at 2 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Memory and Aging Center, University of California, San Francisco

    San Francisco, Californiano site contact published

  • University of Texas

    Austin, Texasno site contact published

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Maya Henry, PhD · PRINCIPAL_INVESTIGATOR · University of Texas at Austin

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

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Eligibility criteria

Inclusion

Meets diagnostic criteria for PPA
Meets diagnostic criteria for a specific variant of PPA
Score of 20 or higher on the Mini-Mental State Examination
Adequate hearing and vision (with hearing or vision aids, if needed)
Has a study partner that can co-enroll in the study and attend pre-treatment training as well as continue to be present for weekly teleconference meetings
Able and willing to undergo MRI brain scan
Access to high speed internet

Exclusion

Speech and language deficits better accounted for by another neurological disorder
Does not meet diagnostic criteria for a specific variant of PPA
Score of less than 20 on the Mini-Mental State Examination
Does not have a study partner who can co-enroll in the study
Contraindications for tDCS or MRI scan (History of seizures, head injury, craniotomy, skull surgery or fracture; History of severe or frequent migraines; Metallic implant in head or any metal in head; Pacemaker or cardioverter-defibrillator or any other stimulator; Chronic skin problems; Pregnancy)
History of stroke, epilepsy, or significant brain injury

What this trial measures

  • RS-LRT arm: Change in spoken namingchange from pre-treatment to one month and three months after onset of treatment in each phase (stimulation and sham)

    Change in percent correctly named trained/untrained pictures

  • RS-VISTA arm: Change in script production accuracychange from pre-treatment to one month and three months after onset of treatment in each phase (stimulation and sham)

    Change in percent correct, intelligible, scripted words produced for trained/untrained scripts