Individual Closed-Loop Neuromodulation Therapy for Alzheimer's Disease
This study is exploring a treatment called transcranial alternating current stimulation (tACS) for people with mild cognitive impairment (MCI) likely due to Alzheimer's disease. Researchers want to see if tACS can change brain activity (natural gamma rhythms) and improve thinking skills. You would receive one of four tACS conditions, including active and sham (inactive) treatments. To join, you should be 50-80 years old, an English speaker, and have MCI likely caused by Alzheimer's, supported by a biomarker (a biological sign of the disease). The study will measure changes in brain activity and cognitive performance after a single 30-minute stimulation session.
- Study design
- This is a placebo-controlled study with plans to enroll 70 participants. It compares different types of tACS to a sham (inactive) treatment.
- What's involved
- You would undergo an EEG (a test that measures brain waves), complete questionnaires, and do computer tasks during each study visit.
- Compensation
- Not stated in the trial record.
- Follow-up
- Changes in brain activity and cognitive performance are measured after a single 30-minute stimulation session.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Individual Closed-Loop Neuromodulation Therapy for Alzheimer's Disease
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Joan Camprodon, MD, PhD, MPH · PRINCIPAL_INVESTIGATOR · MGH, Division of Neuropsychiatry and Neuromodulation
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Changes in the power of entrainment of natural gamma rhythms in patients with AD-MCI.After a single stimulation session (30 minutes).
Measured using closed loop 40 Hertz tACS device
- Changes in cognitive performance in patients with AD-MCI.After a single stimulation session (30 minutes).
Measured using Rey Auditory Verbal Learning Task (RAVLT) which is broken into 6 blocks with each block including a list of 15 words and higher word remembrance in each block indicates a better outcomes, and Face-Name Association Task (FNAT) task where a higher score of matching face to name (out of 60 trials) indicates a better outcome
- Changes in gamma power on cognition in patients with AD-MCI including the effect of baseline neurodegenerative burden/biomarkers. [exploratory]After a single stimulation session (30 minutes).
Measured using Rey Auditory Verbal Learning Task (RAVLT) which is broken into 6 blocks with each block including a list of 15 words and higher word remembrance in each block indicates a better outcomes, and Face-Name Association Task (FNAT) task where a higher score of matching face to name (out of 60 trials) indicates a better outcome, any MRI/PET scans provided prior to study involvement, and changes in gamma power using closed loop 40 Hertz tACS device