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Ultra-Low Contrast Angiography for Acute Kidney Injury

This study is looking at a procedure called coronary angiography, which is used to examine your heart's blood vessels. We want to see if using a very small amount of contrast material (less than 20cc) during this procedure is safe for patients who already have acute kidney injury (AKI). AKI means your kidneys suddenly stop working well. You might be able to join if you are hospitalized, between 18 and 100 years old, have AKI, and need a coronary angiography. The main goal is to see if this low-contrast method can reduce the risk of contrast-induced nephropathy (CIN), which is a type of kidney damage that can happen after receiving contrast material. We will check for CIN within 7 days after the procedure. The study is currently recruiting about 32 participants.

Study design
This is a randomized controlled study where participants are assigned by chance to either immediate angiography or delayed angiography. It is an open-label study, meaning both you and your doctors will know which group you are in.
What's involved
You would have blood tests (serum creatinine) at enrollment, before the angiography, and at 24 hours, 48 hours, and one week after the angiography. If needed, a percutaneous coronary intervention would be scheduled 7 days after the angiography.
Compensation
Not stated in the trial record.
Follow-up
Your kidney function will be monitored for up to 7 days after the angiography procedure.

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NCT05906758

Ultra-Low Contrast Angiography in AKI

Recruiting
PHASE3Ages 18+InterventionalTreatment
Tulane University
~32 participants
Updated 2026-05-18 on ClinicalTrials.gov
What's tested:Angiography

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in incidence of Contrast Induced Nephropathy (CIN)
Measured over Within 7 days

Conditions

Acute Kidney Injury

Explore related trials

Acute Renal Failure

Where it's being run

2 sites across 1 states
Louisiana2

Study leadership

  • Zach Rozenbaum, MD · PRINCIPAL_INVESTIGATOR · Tulane University

Who to contact

Zach Rozenbaum, MD
[email protected]
504-988-5493
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Hospitalized patients who have AKI at admission or who develop AKI during admission and require invasive coronary angiography will be included in the trial.

Exclusion

Stabilized renal function manifested by unchanged or downtrending serum creatinine during a 24-hour period prior to enrollment.
Contraindication for invasive coronary angiography other than AKI.
Percutaneous coronary intervention is indicated and cannot be postponed by 7 days.
Need for renal replacement therapy before coronary angiography or planned renal replacement therapy after coronary angiography (if premeditated before coronary angiography).
Administration of intravascular contrast media during 7 days prior to the coronary angiography or within 6 days after coronary angiography.
Pregnant patients, prisoners, cognitively impaired subjects, age below 18 years, unable or unwilling to provide informed consent.

What this trial measures

  • Change in incidence of Contrast Induced Nephropathy (CIN)Within 7 days

    CIN is defined as an increase in serum creatinine by 0.5mg/dl or a relative rise of 25% from the baseline value. The investigators will measure the incidence of CIN by the increase in serum creatinine to see if the incidence will be the same in both arms whether the patient received the immediate angiography or if it was delayed until kidney function has been stabilized.