Understanding How Humans Learn and Remember New Information
This study, called "Human Learning of New Structured Information Across Time and Sleep," is looking for 105 healthy volunteers aged 18 to 35 to understand how people learn and remember new information, especially how sleep affects this process. You'll participate in different learning activities, like "associative inference" and "category learning," and your memory will be tested. Researchers will also use functional magnetic resonance imaging (fMRI), a type of brain scan, to see how your brain works during these tasks. In one part of the study, you'll sleep after a learning task while your brain activity is measured with electroencephalography (EEG). The main goal is to see how brain activity changes during learning and how it relates to your memory over a week.
- Study design
- This interventional study plans to enroll 105 participants. It is not specified if it is randomized or blinded.
- What's involved
- You would participate in a first session lasting 2-3 hours, and a second session about one week later lasting 1-2 hours. This includes engaging in learning tasks, memory assessments, and potentially undergoing fMRI and EEG scans.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your brain activity and memory will be assessed approximately one week after the first session.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Human Learning of New Structured Information Across Time and Sleep
At a glance
Conditions
NCT05910762
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
University of Pennsylvania
Philadelphia, Pennsylvaniano site contact published
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Anna C Schapiro, PhD · PRINCIPAL_INVESTIGATOR · University of Pennsylvania
Who to contact
This trial hasn't published a contact. View it on ClinicalTrials.gov
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Inclusion
Exclusion
What this trial measures
- Changes in multivariate representationsWithin first session (spanning 2-3 hrs.) and at approximately one week delay in second session (spanning 1-2 hrs.)
Changes in spatial correlations between the MRI BOLD pattern associated with related objects over the course of learning and across the one-week delay.
- Brain-behavior correlationsWithin first session (spanning 2-3 hrs.) and at approximately one week delay in second session (spanning 1-2 hrs.)
Correlations between BOLD signal in the brain and participant behavior during judgments about objects.
- Correlations between activity across brain regionsWithin first session (spanning 2-3 hrs.) and at approximately one week delay in second session (spanning 1-2 hrs.)
Relationships between BOLD activity across different regions of the brain as a function of trial type and delay.
- Memory accuracyWithin single study session (spanning 4-5 hrs.)
Change in generalization ability from before to after the nap as a function of the different conditions of object cueing during sleep.