Improving Physical Function for Older Adults with Cancer Undergoing Surgery

This study is for Veterans aged 55 and older who have certain types of cancer (bladder, colon, kidney, liver, pancreas, stomach, rectum, prostate, endometrium, ovaries, and uterus) and are having surgery soon. It aims to see if a special nutrition and exercise plan can help you stay strong and recover better after surgery. You would receive either a structured nutrition and exercise plan (including protein, Hydroxymethylbutyrate, vitamin D3, and multivitamins) or a standard nutrition and exercise counseling. Researchers will measure your walking ability (6-Minute Walk Test) before and after surgery to see if the special plan helps improve or maintain your physical function. The current recruitment status is unclear.

Study design
This interventional study plans to enroll 188 participants and will compare two different nutrition and exercise approaches.
What's involved
You would receive nutrition counseling and be prescribed a diet and supplements, along with exercise guidance, starting 2-8 weeks before surgery and continuing for 24 weeks after surgery discharge.
Compensation
Not stated in the trial record.
Follow-up
Your physical function will be measured at several points: before surgery, 30 days after surgery, 12 weeks after your post-op visit, and 24 weeks after your post-op visit.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05912257

Preserving Physical Function in Older Adults With Cancer: Impact of an Optimizing Nutrition Intervention Applied Before and After Surgery

Recruiting
NAAges 55+Interventional
VA Office of Research and Development
~188 participants
Updated 2026-05-20 on ClinicalTrials.gov
What's tested:Structured perioperative nutrition and exerciseNutrition and Exercise Counseling

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
6-Minute Walk Change
Measured over baseline, within 72 hours before surgery, 30-days post-op, 12-weeks following post-op visit, 24 weeks following post-op visit
Cancer
1 sites across 1 states
North Carolina1
  • Kathryn N. Starr, PhD · PRINCIPAL_INVESTIGATOR · Durham VA Medical Center, Durham, NC

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime
Eligibility criteria

Inclusion

Male and Female Veterans
Stage I, II, III cancer of the bladder, colon, kidney, liver, pancreas, stomach, rectum, prostate, endometrium, ovaries, and uterus
Surgery 2-8 weeks from consent
Age \> 55 years
Age-normal renal function
English speaking
Able to record dietary intake or has a proxy who can record dietary intake
Willing and able to be randomized to either intervention group

Exclusion

Stage IV cancer diagnosis
Glomerular filtration rates (GFR) less than 45 mL/min
Neurological conditions causing functional impairments, including Parkinson's disease, multiple sclerosis, and permanent disability due to stroke
Class III-IV congestive heart failure
Refractory cachexia - medical condition that affects ability to increase muscle mass (e.g., cachexia) defined as 10% weight loss in 10 months, 5% weight loss in 6 months or 2% weight loss over any period plus body mass index 20 kg/m2 AND Life expectancy 9 months
Active treatment for another cancer site
Body weight \>450 lbs
Uncontrolled diabetes (HbA1c 9%)
Recent diagnosis of thyroid disease or untreated thyroid disease
Inability to complete physical function assessment
Severe dietary restrictions
On chemotherapy drug Sorafenib
  • 6-Minute Walk Changebaseline, within 72 hours before surgery, 30-days post-op, 12-weeks following post-op visit, 24 weeks following post-op visit

    Distance walked in 6 minute.