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Understanding Lifestyle Changes and Metabolic Health

This study is looking at how changes in lifestyle, specifically less physical activity and more sugar-sweetened drinks, affect your body's ability to use sugar (insulin resistance) and regulate blood sugar. We want to see if these changes impact how your body breaks down fats and carbohydrates. You might be able to join if you are a recreationally active young adult, aged 18-30, with good heart and lung fitness. The study will compare different groups: some will reduce physical activity and drink sugary beverages, some will only reduce physical activity, and others will maintain high physical activity while drinking sugary beverages. The main goals are to see how these lifestyle changes affect insulin resistance, 24-hour blood sugar control, and fat burning after 10 days. The current recruitment status is unclear.

Study design
This is an interventional study involving 45 young men and women. Participants will be assigned to one of several groups to compare different lifestyle changes.
What's involved
Participants will transition to a specific lifestyle (low or high physical activity, with or without added sugar-sweetened beverages) for 10 days.
Compensation
Not stated in the trial record.
Follow-up
Measurements will be taken at 10 days to assess the effects of the lifestyle changes.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05912348

The Effects of an Obesogenic Lifestyle in Recreationally Active, Young Adults

Recruiting
NAAges 18–30InterventionalBasic science
University of New Hampshire
~45 participants
Updated 2024-07-17 on ClinicalTrials.gov
What's tested:Low Physical Activity and Added Carbohydrate GroupLow physical Activity ControlHigh Physical Activity and Added Carbohydrate Group

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
To determine if low physical activity alone contributes to insulin resistance in healthy, recreationally active young men and women compared to men and women that reduce their physical activity and consume added sugar-sweetened beverages.
Measured over 10 days
+2 more outcomes measured

Conditions

Insulin Resistance
Impaired Glucose Tolerance
Obesity
Metabolic Disturbance

Explore related trials

Glucose IntoleranceInsulin ResistanceMetabolic DisturbanceObesity

Where it's being run

1 sites across 1 states
New Hampshire1

Study leadership

  • Michael S Brian, PhD · PRINCIPAL_INVESTIGATOR · University of New Hampshire

Who to contact

Michael Brian, PhD
[email protected]
603-714-8899
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

18-30 years of age
Recreationally active completing 75-150 minutes of moderate-to-vigorous intensity exercise (\>2 days/week).
Fair cardiorespiratory fitness levels (Men: VO2\>38.4 ml/kg/min; Women: VO2\>32.6 ml/kg/min).

Exclusion

Hypertension (resting or diagnosed)
Impaired fasting blood glucose (\>100mg/dL)
Diagnosed cardiovascular disease
Diagnosed diabetes
Diagnosed cancer
Diagnosed chronic kidney disease
Diagnosed musculoskeletal disorders that prevents the individual from exercising on a bike.

What this trial measures

  • To determine if low physical activity alone contributes to insulin resistance in healthy, recreationally active young men and women compared to men and women that reduce their physical activity and consume added sugar-sweetened beverages.10 days

    We will use HOMA-IR to measure changes in insulin resistance across the 4 study groups

  • To determine if the combined low physical activity and added carbohydrates impairs 24-hour glucose regulation compared the other study interventions.10 days

    Compare 24-hour glucose regulation (mmol/L) measurements across the four study groups

  • To determine if fat oxidation is impaired when participants reduce their physical activity levels and consume added carbohydrates compared to the three interventions10 days

    Compare the change in fat oxidation after the 10 day intervention