Combined Respiratory Training in Persons With ALS

This study is looking at how a combined respiratory muscle strength training program, called LVR+EMST (Lung Volume Recruitment and Expiratory Muscle Strength Training), affects people with ALS (Amyotrophic Lateral Sclerosis). Researchers want to see if this daily 5-week training can improve cough strength and breathing, and also how it impacts shortness of breath (dyspnea) and problems with speaking or swallowing (bulbar impairment). They will also look at how it affects the quality of life for patients and their caregivers. You might be able to join if you are 18-90 years old, have probable or definite ALS diagnosed within the last two years, haven't used LVR or EMST before, and have reduced peak cough flow (how fast you can cough). The study is currently unclear on its recruitment status.

Study design
This interventional study plans to enroll 34 participants with ALS. It uses a delayed start design where each participant serves as their own control.
What's involved
Participation involves three in-person evaluations and four weekly telehealth therapy sessions. You will also complete daily training for 5 weeks.
Compensation
Not stated in the trial record.
Follow-up
Your peak cough flow will be measured from baseline to the final evaluation at 10 weeks.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05913882

Combined Respiratory Training in Persons With ALS

Recruiting
NAAges 18–90InterventionalTreatment
Nova Southeastern University
~34 participants
Updated 2025-12-23 on ClinicalTrials.gov
What's tested:Respiratory Muscle Strength Training (LVR+EMST)

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Peak Cough Flow
Measured over From Baseline 1 to Final Evaluation (10 weeks)
ALS
Respiratory Insufficiency
Dysphagia

NCT05913882

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Nova Southeastern University

    Fort Lauderdale, Floridastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Magalie Thomas, MBA · STUDY_CHAIR · Nova Southeastern University

Opens a ready-to-send draft in your own email app — review before sending.

  • Peak Cough FlowFrom Baseline 1 to Final Evaluation (10 weeks)

    Greatest cough measurement measured in liters/minute.