Metformin for Microvascular Dysfunction After Gestational Diabetes
This study is looking at how metformin hydrochloride, a common medication, might help improve blood vessel function in women who have had gestational diabetes. Researchers want to understand why some women develop heart and blood vessel problems after gestational diabetes and if metformin can help prevent this. You may be able to join if you are a woman between 18 and 45 years old, are 12 weeks to 5 years postpartum, and had gestational diabetes or a healthy pregnancy. The study will measure your blood flow response to acetylcholine (a substance that affects blood vessels) at the beginning, after 1 week, and after 6 weeks of treatment. The current recruitment status is unclear.
- Study design
- This interventional study plans to enroll 30 women. Participants will receive either metformin hydrochloride or a placebo (an inactive substance) for 12 weeks.
- What's involved
- You would take a tablet once daily for the first 7 days, then twice daily for the remaining 11 weeks. Your blood flow response to acetylcholine will be measured at baseline, 1 week, and 6 weeks.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your blood flow response will be measured at baseline, 1 week, and 6 weeks of treatment.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Metformin for the Treatment of Microvascular Dysfunction After Gestational Diabetes
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Anna Stanhewicz, PhD · PRINCIPAL_INVESTIGATOR · University of Iowa
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- blood flow response to acetylcholinebaseline
cutaneous microvascular dilation (cutaneous conductance ; %max) response to acetylcholine
- blood flow response to acetylcholine1 week of treatment
cutaneous microvascular dilation (cutaneous conductance ; %max) response to acetylcholine
- blood flow response to acetylcholine6 weeks of treatment
cutaneous microvascular dilation (cutaneous conductance ; %max) response to acetylcholine
- blood flow response to acetylcholine12 weeks of treatment
cutaneous microvascular dilation (cutaneous conductance ; %max) response to acetylcholine
- blood flow response to insulinbaseline
cutaneous microvascular dilation (cutaneous conductance ; %max) response to insulin
- blood flow response to insulin1 week of treatment
cutaneous microvascular dilation (cutaneous conductance ; %max) response to insulin
- blood flow response to insulin6 weeks of treatment
cutaneous microvascular dilation (cutaneous conductance ; %max) response to insulin
- blood flow response to insulin12 weeks of treatment
cutaneous microvascular dilation (cutaneous conductance ; %max) response to insulin