This study is for severely obese patients (BMI ≥40 kg/m2) who have been on a breathing machine (ventilator) for at least 24 hours and are ready to have their breathing tube removed. It aims to see if using noninvasive breathing support right after the tube is removed can prevent patients from needing the breathing tube again. You would receive either noninvasive ventilation (NIV) alternating with high flow nasal cannula (HFNC) for 24 hours, or HFNC alone for 24 hours. The main goal is to see if these treatments reduce the need for rescue breathing support within 72 hours after the breathing tube is removed. The study plans to enroll 250 participants, but its current status is unclear.

Study design

This is an interventional study comparing two types of breathing support. It plans to enroll 250 participants.

What's involved

You would receive 24 hours of prophylactic respiratory support using either noninvasive ventilation alternating with high flow nasal cannula, or high flow nasal cannula alone.

Compensation

Not stated in the trial record.

Follow-up

The primary outcome is measured at 72 hours after planned extubation.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.