Dalcetrapib for Heart Attack Risk in a Specific Genetic Group
This study is looking at whether a drug called dalcetrapib can reduce the risk of future heart problems in people who have recently had a heart attack (acute coronary syndrome or ACS). You could be eligible if you are at least 45 years old, have recently been hospitalized for ACS, and have a specific genetic marker called the AA genotype in the ADCY9 gene. This genetic marker will be checked with a special test. The study compares dalcetrapib (300 mg tablets) to a placebo (a pill with no medicine) to see if dalcetrapib can lower the chance of having another heart attack or a fatal heart event. The study aims to enroll 2000 participants, but its current status is unclear.
- Study design
- This is a randomized, double-blind, placebo-controlled study, meaning participants are randomly assigned to receive either dalcetrapib or a placebo, and neither you nor your doctor will know which you are receiving. It is a large study aiming for 2000 participants.
- What's involved
- You will have virtual or clinic visits every 3 months after randomization until the study ends. If you stop taking the study medication early, assessments will continue every 3 months.
- Compensation
- Not stated in the trial record.
- Follow-up
- The study will track your health until approximately 200 participants experience a primary event, with the main outcome measured at an average of 30 months from when you start.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Effect of Dalcetrapib on CV Risk in a Genetically Defined Population With a Recent ACS
At a glance
Conditions
NCT05918861
Where you'd take part
This study runs at 231 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
Research Site
Birmingham, Alabamano site contact published
Recruiting
Research Site
Fairhope, Alabamano site contact published
Recruiting
Research Site
Huntsville, Alabamano site contact published
Recruiting
Research Site
Mobile, Alabamano site contact published
Recruiting
Research Site
Scottsdale, Arizonano site contact published
Recruiting
Research Site
Tucson, Arizonano site contact published
Recruiting
Research Site
North Little Rock, Arkansasno site contact published
Recruiting
Research Site
Huntington Beach, Californiano site contact published
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- David Kallend, MBBS · STUDY_DIRECTOR · DalCor
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
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Inclusion
Exclusion
What this trial measures
- Time to first occurrence of any fatal or non-fatal myocardial infarction (MI)Average of 30 months from randomization
Time to patients experiencing major cardiovascular events