Screening for Early Heart Failure in Primary Care (SYMPHONY-HF)
This study is looking at a new way to find undiagnosed heart failure (HF) in people who are at high risk. You might be able to join if you are 40 or older and have at least two risk factors for heart failure, such as coronary artery disease. Participants will either receive their usual medical care or be in the "investigational arm." In this arm, you'll have a blood test for NT-proBNP (a biomarker that can indicate heart strain). If your NT-proBNP is elevated, you'll have an echocardiogram (an ultrasound of your heart) and a clinical assessment. The goal is to see if this screening strategy can lead to a heart failure diagnosis within 6 months. This study is currently recruiting participants.
- Study design
- This is an international, unblinded, randomized-controlled study involving about 3904 participants. You will be randomly assigned to either receive routine care or be part of the investigational arm.
- What's involved
- If you are in the investigational arm, you will have a blood test for NT-proBNP. If this is elevated, you will then have an echocardiogram, clinical exam, and ECG.
- Compensation
- Not stated in the trial record.
- Follow-up
- The primary goal is to diagnose heart failure within 6 months, so you will be followed up for at least this period.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Screening for earlY Heart Failure Diagnosis and Management in Primary Care or at HOme Using Natriuretic Peptides and echocardiographY "SYMPHONY-HF"
At a glance
Conditions
NCT05919342
Where you'd take part
This study runs at 7 sites. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
Cleveland Clinic
Cleveland, Ohiostudy coordinator listed
Not yet recruiting
Karolinska University Hospital
Stockholm, Swedenstudy coordinator listed
Not yet recruiting
Rigshospitalet, Copenhagen University Hospital
Copenhagen, Denmarkstudy coordinator listed
Not yet recruiting
University of British Columbia
Vancouver, British Columbia, Canadastudy coordinator listed
Not yet recruiting
University of Glasgow
Glasgow, Scotland, United Kingdomstudy coordinator listed
Recruiting
University of Montreal
Montreal, Quebec, Canadastudy coordinator listed
Not yet recruiting
Uppsala University
Uppsala, Swedenstudy coordinator listed
Not yet recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Mark C Petrie, MbChB · PRINCIPAL_INVESTIGATOR · University of Glasgow
- Carolyn SP Lam · PRINCIPAL_INVESTIGATOR · Duke-NUS Graduate Medical School
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
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Inclusion
Exclusion
What this trial measures
- Diagnosis of heart failure within 6 months6 months