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Characterization of Gastric Evoked Potentials

This study is exploring how to best measure "gastric evoked potentials" (GEPs), which are signals from the brain related to stomach activity. Researchers will use a non-invasive brain stimulation method called Transcranial Magnetic Stimulation (TMS) to find the best way to create and record these signals. The study aims to find the ideal TMS settings and brain areas to stimulate GEPs. You may be able to participate if you are a healthy adult between 21 and 60 years old. People with certain medical conditions like psychosis, a history of head injury, or implanted devices cannot join. The study will be successful if it can identify the best locations on the brain and stimulation settings to consistently produce GEPs, and how these change over time.

Study design
This is an interventional study planning to enroll 155 healthy participants.
What's involved
You will attend multiple study sessions over a period of up to 12 months.
Compensation
Not stated in the trial record.
Follow-up
The study will track changes in GEP hotspot location and optimal stimulation parameters for up to 12 months.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05924009

Characterization of Gastric Evoked Potentials

Completed
NAAges 21–60InterventionalBasic science
University of Pittsburgh
~91 participants
Updated 2026-08-14 on ClinicalTrials.gov
What's tested:Transcranial Magnetic Stimulation, TMS

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in GEP hotspot location
Measured over Multiple study sessions spanning up to 12 months
+1 more outcome measured

Conditions

Healthy

Explore related trials

Healthy

Where it's being run

1 sites across 1 states
Pennsylvania1

Study leadership

  • David J Levinthal, MD PhD · PRINCIPAL_INVESTIGATOR · University of Pittsburgh

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Exclusion

psychosis or altered cognitive status
history of head injury, metal in the skull, stroke, or a history of seizures, loss of consciousness or syncope
implantable devices, such as a pacemaker or nerve stimulator
current use of antiepileptic medications or current use of the following medications or substances which are known to lower the seizure threshold: Clozapine (Clozaril), Chlorpromazine (Thorazine), amphetamines or methamphetamine, Ecstasy, Ketamine, Angel Dust/PCP, cocaine, or 3 or more alcoholic drinks per day
pregnancy
BMI \> 30
history of bariatric surgery such as sleeve gastrectomy or Roux-en-Y gastric bypass
diabetes
suffering from a neurodegenerative disorder.

What this trial measures

  • Change in GEP hotspot locationMultiple study sessions spanning up to 12 months

    Stimulation location evoking the largest GEP response, relative to FDI hotspot location

  • Change in optimal stimulation parameters at GEP hotspotMultiple study sessions spanning up to 12 months

    Stimulation pattern (single pulses or brief bursts) and strength relative to MT for FDI