Glaucoma Drainage Device and Endothelial Cell Loss Compare Trial
{ "Glaucoma Drainage Device and Endothelial Cell Loss Compare Trial (DECLARE)", "This study, called DECLARE, is comparing two ways to place a glaucoma drainage device (GDD) during surgery for medically uncontrolled glaucoma. You might be able to join if you are at least 18 years old and need a GDD, or a GDD combined with cataract surgery (phacoemulsification). Researchers want to see if placing the GDD tube in the anterior chamber (front part of the eye) or the ciliary sulcus (a small space between the iris and the front chamber of the eye) leads to less central endothelial cell loss (ECL) in your eye. This cell loss is measured over 12 months. The study is looking for 226 participants, but its current status is unclear.", "design": "This is a randomized study, meaning you would be assigned by chance to one of two groups. It is also \"double-masked,\" so neither you nor your doctors will know which tube placement you receive.", "commitments": "You would undergo GDD implantation surgery with either sulcus tube placement or anterior chamber tube placement. You will be followed for 12 months for the main outcome, and then for a total of 24 months.", "compensation": "Not stated in the trial record.", "follow_up": "Participants will be followed for 12 months for the primary outcome, and then for a total of 24 months.", }
- Study design
- Not specified.
- What's involved
- Not specified in the trial record.
- Compensation
- Not stated in the trial record.
- Follow-up
- Not specified.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Glaucoma Drainage Device and Endothelial Cell Loss Compare Trial
At a glance
Conditions
Where it's being run
8 sites across 7 statesStudy leadership
- Ying Han, MD, PhD · STUDY_CHAIR · University of California, San Francisco
- Jennifer Rose-Nussbaumer, MD · STUDY_DIRECTOR · Stanford University
- Thuy Doan, MD, PhD · STUDY_DIRECTOR · University of California San Fransicso
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Central endothelial cell loss (ECL) from baselineBaseline to 12 months
Change in central endothelial cell density based on assessment of Specular Microscopy images.