Aspirin for Postpartum Preeclampsia

This study is looking at whether low-dose aspirin (Aspirin 81Mg Ec Tab) can help women recover from severe preeclampsia (a high blood pressure condition during pregnancy) after they have given birth. Researchers believe that taking aspirin for the first week after delivery might help by lowering levels of a protein called soluble fms-like tyrosine kinase (sFlt-1), which is thought to contribute to preeclampsia. The goal is to see if aspirin can help blood pressure return to normal more quickly. To join, you must be a woman aged 18 or older who has been diagnosed with severe preeclampsia during your delivery hospital stay, according to ACOG (American College of Obstetricians and Gynecologists) guidelines. You also need to receive your pre- and postnatal care from specific clinics. The study aims to enroll 86 participants, but its current status is unclear.

Study design
This is an interventional study, meaning participants will receive a specific treatment. It plans to enroll 86 women.
What's involved
Participants randomized to receive aspirin will take one 81 mg tablet by mouth nightly at 8:00 PM for one week, starting within 24 hours of delivery. Your sFlt-1 levels will be measured at 1 week postpartum.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for at least 1 week postpartum to measure sFlt-1 levels.

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NCT05924971

Aspirin for Postpartum Patients With Preeclampsia

Recruiting
PHASE2Ages 18+InterventionalTreatment
MemorialCare Health System
~86 participants
Updated 2025-06-06 on ClinicalTrials.gov
What's tested:Aspirin 81Mg Ec Tab

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Reduction in sFlt-1
Measured over 1 week postpartum
Preeclampsia Postpartum
1 sites across 1 states
California1
  • Megan C Oakes, MD MSCI · PRINCIPAL_INVESTIGATOR · Miller Children's and Women's Hospital, Long Beach/ MemorialCare Medical Center

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Eligibility criteria

Inclusion

Preeclampsia with severe features diagnosed during delivery admission, as defined by ACOG criteria.
Pre- and postnatal care provided by the Long Beach Memorial Ob/Gyn resident or Maternal-Fetal Medicine clinic.

Exclusion

Patient age \<18 years old
Non-English or Non-Spanish speaking
Chronic hypertension diagnosed before 20 weeks' gestation
Known allergy, prior adverse reaction, or any medical condition in which aspirin is contraindicated (nasal polyps, gastric or duodenal ulcers, history of gastrointestinal bleeding, severe hepatic dysfunction)
Aspirin prescribed postpartum for any other medical condition
Bleeding disorder
Breastfeeding an infant with thrombocytopenia
  • Reduction in sFlt-11 week postpartum

    This outcome will determine the absolute change in sFlt-1, an anti-angiogenic protein implicated in the pathophysiology of preeclampsia.