C-Protein in Fatigue and Aging Study

This study is looking into how proteins in your muscles change with age, which can lead to weaker muscles. Researchers want to understand the specific ways these proteins contribute to muscle weakness and reduced muscle size. You might be able to join if you are a healthy adult between 18-35 or 65-80 years old, can speak English, and are willing to have a muscle biopsy and do some exercise. The study will involve doing a "Fatiguing Exercise" where you extend your knee using a special chair. The main goal is to see how a specific protein called myosin binding protein c (MyBP-C) changes after this exercise, one week after a muscle biopsy. The current recruitment status is unclear.

Study design: This is an interventional study planning to enroll 24 participants. It involves a specific exercise intervention.
What's involved: You would perform knee extension exercise of one leg and have a muscle biopsy. You would also participate in physical activity monitoring.
Compensation: Not stated in the trial record.
Follow-up: The primary endpoint is measured one week after the muscle biopsies.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

C-Protein in Fatigue and Aging

Recruiting

NAAges 18–80InterventionalBasic science

University of Oregon

~24 participants

Updated 2025-05-07 on ClinicalTrials.gov

What's tested:Fatiguing Exercise

At a glance

Recruiting sites

1 of 1 listed site is recruiting right now

RecruitingSuspended, closed, or not yet open

What they're measuring

Phosphorylation of myosin binding protein c (MyBP-C)

Measured over One week after the participant undergoes the biopsies.

Conditions

Aging

Muscle Atrophy or Weakness

Sarcopenia in Elderly

Sarcopenia

Where it's being run

1 sites across 1 states

Oregon1

Study leadership

Damien M Callahan, Ph.D. · PRINCIPAL_INVESTIGATOR · University of Oregon

Who to contact

Damien M Callahan, Ph.D.

[email protected]

541-346-5040

Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

Check eligibility for this trial ~2 min · HIPAA-protected · delete anytime

Eligibility criteria

Inclusion

Adults between the ages 18-35 or 65-80 years

Healthy by self-report

Willing to participate in all aspects of the study design including muscle biopsy, unilateral exercise, and physical activity monitoring

Fluent in English (due to lack of translation services, it is not practical to conduct the study using a language other than English).

Exclusion

Orthopaedic limitation (severe knee osteoarthritis, prior joint replacement, etc.).

Volunteer has dementia or related mental issues that potentially put the subject at risk as determined by prior diagnosis.

Volunteer has known untreated endocrine disease (hypo/hyper thyroidism, Addison's Disease or Cushing's syndrome, etc.)

Volunteer has untreated/poorly-controlled hypertension (stage 2, per American College of Cardiology \[\>140/90 mmHg\]).

Volunteer has significant heart, liver, kidney or respiratory disease.

Volunteer has diabetes (insulin dependent or non-insulin dependent).

Volunteer has known coagulopathies.

Volunteer has taken anabolic steroids in the prior six months.

Volunteer has received treatment for cancer (other than effective Mohs Surgery for successful removal of basal cell or squamous cell carcinomas)

Unexpected weight loss \>5kg is last 12 months

Volunteer is an active smoker or quit within the last year.

Volunteer has known current alcohol or drug use disorder (AUD; defined as binge drinking of \>4 days in the last month. Binge drinking is \>5 drinks for men and \>4 drinks for women, per occasion). Or, if a volunteer reports drinking in excess of "low risk" per NIAAA (\>7 drinks/week for men and \>3 drinks/day for women and \>14 drinks/week and \>4 drinks/day).

Volunteer has a diagnosed neuromuscular disorder.

Volunteer has allergy to lidocaine.

What this trial measures

Phosphorylation of myosin binding protein c (MyBP-C)One week after the participant undergoes the biopsies.
Muscle tissue is immediately frozen after biopsy. Liquid chromatography and high resolution mass spectrometry will be used to do a full analysis of the phosphorylation sites on MyBP-C isolated from the biopsied muscle tissue.

Trialytics