Song-making In a Group (SING) for Schizophrenia

This study, called Song-making In a Group (SING), is looking into how making music in a group might help people with schizophrenia who hear voices. The study will involve a trained musician leading groups of five participants in four weekly two-hour sessions. During these sessions, you'll have access to instruments and recording equipment to create music. Researchers want to see if this musical intervention can improve how you use language, how you update your social beliefs, and reduce conditioned hallucinations (hearing voices). They are also trying to understand if actively making music is more helpful than just listening, or if creating new music is better than performing existing songs. The study aims to enroll 200 participants aged 18 to 65 who experience daily voice hearing.

Study design
This is an interventional study planning to enroll 200 participants. It is designed to optimize the musical intervention by comparing different ways of participating.
What's involved
You would participate in four weekly two-hour musical intervention sessions. Your language use, social belief updating, and conditioned hallucinations will be measured at the start and within one week after your last session.
Compensation
Not stated in the trial record.
Follow-up
Measurements will be taken within one week of completing the final musical intervention session.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT05929352

Song-making In a Group (SING)

Completed
NAAges 18–65InterventionalBasic science
Yale University
~135 participants
Updated 2026-08-20 on ClinicalTrials.gov
What's tested:Musical Intervention

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in Language Use
Measured over baseline and Within one week of study completion (final MI session of 4)
+2 more outcomes measured
Schizophrenia
1 sites across 1 states
Connecticut1
  • Philip R Corlett, PhD · PRINCIPAL_INVESTIGATOR · Yale University

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

voice hearing patients meeting diagnostic criteria for Diagnostic and Statistical Manual-V psychotic disorder
hearing voices at least once a day
PANSS P3 (Hallucinations item) greater than 3
Prior to study participation all patients will be evaluated for i) protocol eligibility; ii) ability to give informed consent; iii) interaction with the study team to determine participant's probability of completing the study; and iv) ability to cooperate with protocol procedures. The flow of all participants will be reviewed at weekly research meetings in consultation with the study team.

Exclusion

Diagnostic and Statistical Manual-IV substance abuse or dependence (past six months)
clinically significant medical conditions, head injury with neurological symptoms or unconsciousness
mental retardation (IQ\<70)
Non-English speaking
no less than 2 weeks of stable doses of psychotropic medications (to avoid transient effects of medication regiment change; medication type and dose will be carefully recorded and used as a covariate in all analyses)
Co-morbid mood or anxiety diagnosis
clinically/behaviorally unstable and unable to cooperate with SING procedures
Unstable medical condition based on medical history, physical examination and routine laboratory work-up
  • Change in Language Usebaseline and Within one week of study completion (final MI session of 4)

    Speech patterns of participants will be analyzed pre and post intervention using the Linguistic Inquiry and Word Counting Program on interviews conducted prior to and post musical intervention

  • Change in Social Belief Updatingbaseline and Within one week of study completion (final MI session of 4)

    Social belief updating under uncertainty will be analyzed using a probabilistic reversal learning task. Participants will be asked to choose between stimuli on a computer screen that will increase or decrease their points score. Participants should choose the best deck as much as possible, and should understand that the best deck can change from time to time. Points achieved as well as the patterns of errors committed will be analyzed.

  • Change in Conditioned Hallucinationsbaseline and Within one week of study completion (final MI session of 4)

    Participants susceptibility to conditioned hallucinations during a perceptual inference task that presents auditory and visual stimuli through a computer program will be analyzed. Participant reports of hearing tones conditional on visual stimuli will be the key outcome.