Open Trial of Trauma-focused Psychodynamic Psychotherapy for People Living With HIV and PTSD

This study is testing a type of talk therapy called Trauma-focused psychodynamic psychotherapy for people living with HIV (PLWH) who also have Post Traumatic Stress Disorder (PTSD). This therapy helps you explore how past traumatic events might be affecting your emotions and relationships. The study aims to see if this therapy is helpful and acceptable for PLWH with PTSD. To join, you must be between 18 and 65 years old, have a diagnosis of PTSD and HIV, and be on stable psychiatric medication for at least two months. The study will measure success by looking at changes in your PTSD symptoms over 12 weeks. The current recruitment status is unclear, and the study plans to enroll 20 participants.

Study design
This is an interventional study, meaning participants will receive a specific treatment. It plans to enroll 20 participants.
What's involved
The primary endpoints are measured at Baseline, Week 6, and Week 12 (treatment termination).
Compensation
Not stated in the trial record.
Follow-up
Participants are followed until Week 12, which is when treatment ends.

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NCT05929911

Open Trial of Trauma-focused Psychodynamic Psychotherapy for People Living With HIV and PTSD

Recruiting
NAAges 18–65InterventionalTreatment
Montefiore Medical Center
~20 participants
Updated 2026-06-12 on ClinicalTrials.gov
What's tested:Trauma-focused psychodynamic psychotherapy

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in PTSD Score based on the Clinician Administered PTSD Scale for DSM-5
Measured over Baseline
+3 more outcomes measured
Post Traumatic Stress Disorder (PTSD)
HIV
1 sites across 1 states
New York1
  • Barbara Milrod, MD · PRINCIPAL_INVESTIGATOR · Montefiore Medical Center

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Eligibility criteria

Inclusion

Diagnosis of DSM-5 defined PTSD, per the Clinician Administered PTSD Scale \& CAPS-5 total severity score greater than or equal to 25
HIV diagnosis (by medical records or HIV testing)
Stable psychiatric/psychotropic medication for \>=2 months and ongoing during treatment

Exclusion

Psychosis
Bipolar I
Acute suicidality
Current substance use disorder
Organic mental syndrome or intellectual disability
Unstable non-HIV medical conditions
  • Change in PTSD Score based on the Clinician Administered PTSD Scale for DSM-5Baseline

    Lower scores denote less severe PTSD symptoms; a decline of at least 30% from an individual's baseline CAPS score is defined as a treatment response on the CAPS; diagnostic remission will be defined as achieving response plus failing to meet for DSM-5 defined PTSD per the CAPS after treatment.

  • Change in PTSD Score based on the Clinician Administered PTSD Scale for DSM-5Week 6

    Lower scores denote less severe PTSD symptoms; a decline of at least 30% from an individual's baseline CAPS score is defined as a treatment response on the CAPS; diagnostic remission will be defined as achieving response plus failing to meet for DSM-5 defined PTSD per the CAPS after treatment.

  • Change in PTSD Score based on the Clinician Administered PTSD Scale for DSM-5Week 12 (treatment termination)

    Lower scores denote less severe PTSD symptoms; a decline of at least 30% from an individual's baseline CAPS score is defined as a treatment response on the CAPS; diagnostic remission will be defined as achieving response plus failing to meet for DSM-5 defined PTSD per the CAPS after treatment.

  • Change in PTSD Score based on the Clinician Administered PTSD Scale for DSM-53-month post-treatment follow-up

    Lower scores denote less severe PTSD symptoms; a decline of at least 30% from an individual's baseline CAPS score is defined as a treatment response on the CAPS; diagnostic remission will be defined as achieving response plus failing to meet for DSM-5 defined PTSD per the CAPS after treatment.