This observational study is looking for ways to better understand Rett Syndrome (RTT) by identifying specific markers in the brain. Researchers will use an electroencephalogram (EEG) and Evoked Potentials (AEP and VEP) to measure electrical activity in the brain. They want to see if these brain activity patterns change as RTT symptoms change, stay the same in stable individuals, and if they are linked to how severe RTT is. You may be able to join if you are a female between 1 and 18 years old with a diagnosis of Rett Syndrome or a specific genetic change (MECP2 variant). The study aims to measure Auditory Evoked Potential (AEP) and Visual Evoked Potential (VEP) latencies and amplitudes over 5 years. The current recruitment status is unclear.

Study design

This is an observational study with a planned enrollment of 202 participants. It will compare findings in individuals with Rett Syndrome to those in typically developing individuals.

What's involved

Participants will undergo up to eight standardized sessions involving EEG and Auditory and Visual Evoked Potentials (AEP and VEP). Clinical assessments will also be collected.

Compensation

Not stated in the trial record.

Follow-up

The primary endpoints for Auditory Evoked Potential (AEP) and Visual Evoked Potential (VEP) are measured at 5 years.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.