E-cigarette Coolant Study for Adults with Nicotine Use Disorder
This study is looking at how different cooling ingredients in e-liquids affect how much people like e-cigarettes and their potential for addiction. Researchers are testing e-liquids with different levels of menthol, WS-3, and WS-23 (synthetic coolants). You could join if you are an adult (18+) who currently uses e-cigarettes, can read and write, and have a certain level of nicotine in your urine (cotinine ≥200ng/ml). The study will measure how much you like each e-cigarette, how reinforcing it feels, and if it causes irritation or harshness. The goal is to understand how these coolants influence the appeal and addiction potential of e-cigarettes. The study plans to enroll 66 participants, but its current status is unclear.
- Study design
- This interventional study plans to enroll 66 adult e-cigarette users. Participants will be exposed to various e-liquid coolants in a randomized order across three lab sessions.
- What's involved
- You will participate in 3 laboratory sessions. During these sessions, you will try different e-cigarette conditions and rate their flavor, coolness, sweetness, irritation/harshness, and bitterness.
- Compensation
- Not stated in the trial record.
- Follow-up
- Your responses to the e-cigarette conditions will be measured at specific times (10 minutes, 40 minutes, etc.) following each administration during the lab sessions.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Effects of Novel E-cigarette Constituents on Adults TCORS 3.0
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Suchitra Krishnan-Sarin, PhD · PRINCIPAL_INVESTIGATOR · Yale University
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Liking: Score change in liking/wanting of each e-cigarette condition (5 conditions in total)Following administration of e-cigarette condition 1 (at 10 minutes), following administration of e-cigarette condition 2 (at 40 minutes)...following administration of e-cigarette condition 6 (at 160 minutes)
The Labeled Hedonic Scale will be used to ask about liking and wanting of the e-cigarette (one item Visual Analog Scale with ratings ranging from "most disliked sensation imaginable" to "most liked sensation imaginable" with higher values indicating greater liking).
- Reinforcing Efficacy: Score change in drug effects of each e-cigarette condition (5 conditions in total)Following administration of e-cigarette condition 1 (at 10 minutes), following administration of e-cigarette condition 2 (at 40 minutes)...following administration of e-cigarette condition 6 (at 160 minutes)
Difference between e-cigarette effects for each e-cigarette condition as measured by the computerized version of the Drug Effects Questionnaire (DEQ). Participants will self-report their responses using a computer mouse to indicate where on the scale response falls. A modified version of the Drug Effects Questionnaire (DEQ) will be used in which participants rate acute responses to the e-cigarette on a 0-100mm scale from "not at all" (0mm) to "extremely" (100mm).
- Irritation/Harshness: Score change in irritation of harshness of each e-cigarette condition (5 conditions in total)Following administration of e-cigarette condition 1 (at 10 minutes), following administration of e-cigarette condition 2 (at 40 minutes)...following administration of e-cigarette condition 6 (at 160 minutes)
Difference in irritation at each e-cigarette condition as measured by the computerized Generalized Labeled Magnitude Scale (gLMS). Participants will self-report their responses using a computer mouse to indicate where on the scale response falls. The Generalized Labeled Magnitude Scales (gLMS) are category ratio scales with seven semantic labels: "no sensation", "barely detectable", "weak", "moderate", "strong", "very strong", and "strongest imaginable", positioned quasi-logarithmically as per empirically determined semantic magnitudes on a 0-100 scale (strongest imaginable at the 100 end).