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Lupus Landmark Study: A Registry and Biorepository

This study is creating a registry and biorepository (a collection of biological samples) for people with Systemic Lupus Erythematosus (SLE), also known as lupus. The goal is to gather clinical information and biological samples like blood and urine over many years to help researchers better understand lupus, including Lupus Nephritis (kidney inflammation caused by lupus) and Neuropsychiatric Systemic Lupus Erythematosus (lupus affecting the brain or nervous system). This will help identify genetic factors, targets for new treatments, and how different people respond to therapies. You may be able to join if you are 18 years or older and have a diagnosis of lupus. The study aims to enroll over 3500 people, but the current recruitment status is unclear.

Study design
This is an observational study, meaning participants will be followed over time without receiving a specific intervention. It aims to enroll over 3500 individuals.
What's involved
You would provide clinical data, allow access to your medical records, and provide biological samples such as whole blood, urine, saliva, stool, and tissue.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for up to 25 years to identify genetic drivers and correlate biomarkers to therapeutic responses.

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NCT05934149

Lupus Landmark Study: A Prospective Registry and Biorepository

Recruiting
Not specifiedAges 18+Observational
Lupus Research Alliance
~3,500 participants
Updated 2026-04-15 on ClinicalTrials.gov

At a glance

Recruiting sites
22 of 25 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Identify genetic drivers and antigenic targets, to elucidate mechanistic heterogeneity and correlate biomarkers to therapeutic responses.
Measured over up to 25 years

Conditions

Systemic Lupus Erythematosus (SLE)
Lupus Nephritis
Neuropsychiatric Systemic Lupus Erythematosus

Explore related trials

Lupus GlomerulonephritisNeuropsychiatric Systemic Lupus ErythematosusSystemic Lupus Erythematosus

Where it's being run

25 sites across 18 states
New York4
California2
Massachusetts2
Alberta2
Quebec2
Alabama1
Arizona1
District of Columbia1

Study leadership

  • Sam Lim, MD, MPH · PRINCIPAL_INVESTIGATOR · Emory University
  • Arezou Khosroshahi, MD · PRINCIPAL_INVESTIGATOR · Emory University
  • Alfred Kim, MD, PhD · PRINCIPAL_INVESTIGATOR · Washington University School of Medicine

Who to contact

Lupus Nexus Director
[email protected]
646-884-6084
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Able to understand and comply with study procedures and voluntarily sign a written informed consent document
Age 18 years or older at the time of enrollment
Fulfill criteria for SLE based on one or more of the following classifications systems:

Exclusion

Not able to obtain consent
Not able to meet protocol visit requirements
Pregnant at the time of enrollment

What this trial measures

  • Identify genetic drivers and antigenic targets, to elucidate mechanistic heterogeneity and correlate biomarkers to therapeutic responses.up to 25 years

    Resource intended to be used to address research questions based upon three categorical time frames (historical, cross-sectional, and longitudinal) with specified scientific topics proposed upon request to access the resources.